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Anti-HYAL2/ LUCA2 monoclonal antibody
Anti-HYAL2/ LUCA2 antibody for FACS & in-vivo assay
Go to HYAL2/HYAL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0596-Ab-1/ GM-Tg-hg-MP0596-Ab-2 | Anti-Human HYAL2 monoclonal antibody | Human |
| GM-Tg-rg-MP0596-Ab-1/ GM-Tg-rg-MP0596-Ab-2 | Anti-Rat HYAL2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0596-Ab-1/ GM-Tg-mg-MP0596-Ab-2 | Anti-Mouse HYAL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0596-Ab-1/ GM-Tg-cynog-MP0596-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HYAL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0596-Ab-1/ GM-Tg-felg-MP0596-Ab-2 | Anti-Feline HYAL2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0596-Ab-1/ GM-Tg-cang-MP0596-Ab-2 | Anti-Canine HYAL2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0596-Ab-1/ GM-Tg-bovg-MP0596-Ab-2 | Anti-Bovine HYAL2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0596-Ab-1/ GM-Tg-equg-MP0596-Ab-2 | Anti-Equine HYAL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0596-Ab-1/ GM-Tg-hg-MP0596-Ab-2; GM-Tg-rg-MP0596-Ab-1/ GM-Tg-rg-MP0596-Ab-2; GM-Tg-mg-MP0596-Ab-1/ GM-Tg-mg-MP0596-Ab-2; GM-Tg-cynog-MP0596-Ab-1/ GM-Tg-cynog-MP0596-Ab-2; GM-Tg-felg-MP0596-Ab-1/ GM-Tg-felg-MP0596-Ab-2; GM-Tg-cang-MP0596-Ab-1/ GM-Tg-cang-MP0596-Ab-2; GM-Tg-bovg-MP0596-Ab-1/ GM-Tg-bovg-MP0596-Ab-2; GM-Tg-equg-MP0596-Ab-1/ GM-Tg-equg-MP0596-Ab-2 |
| Products Name | Anti-HYAL2 monoclonal antibody |
| Format | mab |
| Target Name | HYAL2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HYAL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HYAL2/ LUCA2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm001773 | mouse Hyal2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001773 | mouse Hyal2 Lentivirus particle |
Target information
| Target ID | GM-MP0596 |
| Target Name | HYAL2 |
| Gene ID | 8692,15587,64468,702484,281838,100061845 |
| Gene Symbol and Synonyms | HYAL2,LUCA2 |
| Uniprot Accession | Q12891,Q9Z2Q3,Q8SQG8 |
| Uniprot Entry Name | HYAL2_HUMAN,HYAL2_RAT,HYAL2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000068001 |
| Target Classification | N/A |
The target: HYAL2, gene name: HYAL2, also named as LUCA2. This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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