Anti-ICAM3/ CD50/ CDW50 monoclonal antibody

Anti-ICAM3/ CD50/ CDW50 antibody for FACS & in-vivo assay

Target products collectionGo to ICAM3/ICAM3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0598-Ab-1/ GM-Tg-hg-MP0598-Ab-2Anti-Human ICAM3 monoclonal antibodyHuman
GM-Tg-rg-MP0598-Ab-1/ GM-Tg-rg-MP0598-Ab-2Anti-Rat ICAM3 monoclonal antibodyRat
GM-Tg-mg-MP0598-Ab-1/ GM-Tg-mg-MP0598-Ab-2Anti-Mouse ICAM3 monoclonal antibodyMouse
GM-Tg-cynog-MP0598-Ab-1/ GM-Tg-cynog-MP0598-Ab-2Anti-Cynomolgus/ Rhesus macaque ICAM3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0598-Ab-1/ GM-Tg-felg-MP0598-Ab-2Anti-Feline ICAM3 monoclonal antibodyFeline
GM-Tg-cang-MP0598-Ab-1/ GM-Tg-cang-MP0598-Ab-2Anti-Canine ICAM3 monoclonal antibodyCanine
GM-Tg-bovg-MP0598-Ab-1/ GM-Tg-bovg-MP0598-Ab-2Anti-Bovine ICAM3 monoclonal antibodyBovine
GM-Tg-equg-MP0598-Ab-1/ GM-Tg-equg-MP0598-Ab-2Anti-Equine ICAM3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0598-Ab-1/ GM-Tg-hg-MP0598-Ab-2; GM-Tg-rg-MP0598-Ab-1/ GM-Tg-rg-MP0598-Ab-2;
GM-Tg-mg-MP0598-Ab-1/ GM-Tg-mg-MP0598-Ab-2; GM-Tg-cynog-MP0598-Ab-1/ GM-Tg-cynog-MP0598-Ab-2;
GM-Tg-felg-MP0598-Ab-1/ GM-Tg-felg-MP0598-Ab-2; GM-Tg-cang-MP0598-Ab-1/ GM-Tg-cang-MP0598-Ab-2;
GM-Tg-bovg-MP0598-Ab-1/ GM-Tg-bovg-MP0598-Ab-2; GM-Tg-equg-MP0598-Ab-1/ GM-Tg-equg-MP0598-Ab-2
Products NameAnti-ICAM3 monoclonal antibody
Formatmab
Target NameICAM3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ICAM3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ICAM3/ CD50/ CDW50 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0598
    Target NameICAM3
    Gene ID3385,715298,100683931,101094485,281840,100058074
    Gene Symbol and SynonymsCD50,CDW50,ICAM-R,ICAM3
    Uniprot AccessionP32942,Q28125
    Uniprot Entry NameICAM3_HUMAN,ICAM3_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000076662
    Target ClassificationN/A

    The target: ICAM3, gene name: ICAM3, also named as CD50, CDW50, ICAM-R. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.