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Anti-ICAM4/ CD242/ LW monoclonal antibody
Anti-ICAM4/ CD242/ LW antibody for FACS & in-vivo assay
Go to ICAM4/ICAM4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0599-Ab-1/ GM-Tg-hg-MP0599-Ab-2 | Anti-Human ICAM4 monoclonal antibody | Human |
| GM-Tg-rg-MP0599-Ab-1/ GM-Tg-rg-MP0599-Ab-2 | Anti-Rat ICAM4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0599-Ab-1/ GM-Tg-mg-MP0599-Ab-2 | Anti-Mouse ICAM4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0599-Ab-1/ GM-Tg-cynog-MP0599-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ICAM4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0599-Ab-1/ GM-Tg-felg-MP0599-Ab-2 | Anti-Feline ICAM4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0599-Ab-1/ GM-Tg-cang-MP0599-Ab-2 | Anti-Canine ICAM4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0599-Ab-1/ GM-Tg-bovg-MP0599-Ab-2 | Anti-Bovine ICAM4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0599-Ab-1/ GM-Tg-equg-MP0599-Ab-2 | Anti-Equine ICAM4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0599-Ab-1/ GM-Tg-hg-MP0599-Ab-2; GM-Tg-rg-MP0599-Ab-1/ GM-Tg-rg-MP0599-Ab-2; GM-Tg-mg-MP0599-Ab-1/ GM-Tg-mg-MP0599-Ab-2; GM-Tg-cynog-MP0599-Ab-1/ GM-Tg-cynog-MP0599-Ab-2; GM-Tg-felg-MP0599-Ab-1/ GM-Tg-felg-MP0599-Ab-2; GM-Tg-cang-MP0599-Ab-1/ GM-Tg-cang-MP0599-Ab-2; GM-Tg-bovg-MP0599-Ab-1/ GM-Tg-bovg-MP0599-Ab-2; GM-Tg-equg-MP0599-Ab-1/ GM-Tg-equg-MP0599-Ab-2 |
| Products Name | Anti-ICAM4 monoclonal antibody |
| Format | mab |
| Target Name | ICAM4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ICAM4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ICAM4/ CD242/ LW VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002121 | human ICAM4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002121 | human ICAM4 Lentivirus particle |
| ORF Viral Vector | pGMLPm004587 | mouse Icam4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004587 | mouse Icam4 Lentivirus particle |
Target information
| Target ID | GM-MP0599 |
| Target Name | ICAM4 |
| Gene ID | 3386,78369,298702,712354,101093754,514873,100055305 |
| Gene Symbol and Synonyms | 1810015M19Rik,CD242,ICAM-4,ICAM4,LW |
| Uniprot Accession | Q14773 |
| Uniprot Entry Name | ICAM4_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105371 |
| Target Classification | N/A |
The target: ICAM4, gene name: ICAM4, also named as CD242, LW. This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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