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Anti-ICAM5/ TLCN/ TLN monoclonal antibody
Anti-ICAM5/ TLCN/ TLN antibody for FACS & in-vivo assay
Go to ICAM5/ICAM5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0600-Ab-1/ GM-Tg-hg-MP0600-Ab-2 | Anti-Human ICAM5 monoclonal antibody | Human |
| GM-Tg-rg-MP0600-Ab-1/ GM-Tg-rg-MP0600-Ab-2 | Anti-Rat ICAM5 monoclonal antibody | Rat |
| GM-Tg-mg-MP0600-Ab-1/ GM-Tg-mg-MP0600-Ab-2 | Anti-Mouse ICAM5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0600-Ab-1/ GM-Tg-cynog-MP0600-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ICAM5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0600-Ab-1/ GM-Tg-felg-MP0600-Ab-2 | Anti-Feline ICAM5 monoclonal antibody | Feline |
| GM-Tg-cang-MP0600-Ab-1/ GM-Tg-cang-MP0600-Ab-2 | Anti-Canine ICAM5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0600-Ab-1/ GM-Tg-bovg-MP0600-Ab-2 | Anti-Bovine ICAM5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0600-Ab-1/ GM-Tg-equg-MP0600-Ab-2 | Anti-Equine ICAM5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0600-Ab-1/ GM-Tg-hg-MP0600-Ab-2; GM-Tg-rg-MP0600-Ab-1/ GM-Tg-rg-MP0600-Ab-2; GM-Tg-mg-MP0600-Ab-1/ GM-Tg-mg-MP0600-Ab-2; GM-Tg-cynog-MP0600-Ab-1/ GM-Tg-cynog-MP0600-Ab-2; GM-Tg-felg-MP0600-Ab-1/ GM-Tg-felg-MP0600-Ab-2; GM-Tg-cang-MP0600-Ab-1/ GM-Tg-cang-MP0600-Ab-2; GM-Tg-bovg-MP0600-Ab-1/ GM-Tg-bovg-MP0600-Ab-2; GM-Tg-equg-MP0600-Ab-1/ GM-Tg-equg-MP0600-Ab-2 |
| Products Name | Anti-ICAM5 monoclonal antibody |
| Format | mab |
| Target Name | ICAM5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ICAM5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ICAM5/ TLCN/ TLN VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001525 | human ICAM5 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001525 | human ICAM5 Lentivirus particle |
Target information
| Target ID | GM-MP0600 |
| Target Name | ICAM5 |
| Gene ID | 7087,15898,720495,484958,101089676,505158,100146897 |
| Gene Symbol and Synonyms | CD50,ICAM-3,ICAM-5,Icam3,ICAM5,TLCN,TLN |
| Uniprot Accession | Q9UMF0 |
| Uniprot Entry Name | ICAM5_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105376 |
| Target Classification | N/A |
The target: ICAM5, gene name: ICAM5, also named as TLCN, TLN. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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