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Anti-INLR1/ IFNLR1/ CRF2/12 monoclonal antibody
Anti-INLR1/ IFNLR1/ CRF2/12 antibody for FACS & in-vivo assay
Go to IFNLR1/IFNLR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0607-Ab-1/ GM-Tg-hg-MP0607-Ab-2 | Anti-Human IFNLR1 monoclonal antibody | Human |
| GM-Tg-rg-MP0607-Ab-1/ GM-Tg-rg-MP0607-Ab-2 | Anti-Rat IFNLR1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0607-Ab-1/ GM-Tg-mg-MP0607-Ab-2 | Anti-Mouse IFNLR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0607-Ab-1/ GM-Tg-cynog-MP0607-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IFNLR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0607-Ab-1/ GM-Tg-felg-MP0607-Ab-2 | Anti-Feline IFNLR1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0607-Ab-1/ GM-Tg-cang-MP0607-Ab-2 | Anti-Canine IFNLR1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0607-Ab-1/ GM-Tg-bovg-MP0607-Ab-2 | Anti-Bovine IFNLR1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0607-Ab-1/ GM-Tg-equg-MP0607-Ab-2 | Anti-Equine IFNLR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0607-Ab-1/ GM-Tg-hg-MP0607-Ab-2; GM-Tg-rg-MP0607-Ab-1/ GM-Tg-rg-MP0607-Ab-2; GM-Tg-mg-MP0607-Ab-1/ GM-Tg-mg-MP0607-Ab-2; GM-Tg-cynog-MP0607-Ab-1/ GM-Tg-cynog-MP0607-Ab-2; GM-Tg-felg-MP0607-Ab-1/ GM-Tg-felg-MP0607-Ab-2; GM-Tg-cang-MP0607-Ab-1/ GM-Tg-cang-MP0607-Ab-2; GM-Tg-bovg-MP0607-Ab-1/ GM-Tg-bovg-MP0607-Ab-2; GM-Tg-equg-MP0607-Ab-1/ GM-Tg-equg-MP0607-Ab-2 |
| Products Name | Anti-IFNLR1 monoclonal antibody |
| Format | mab |
| Target Name | IFNLR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IFNLR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species INLR1/ IFNLR1/ CRF2/12 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0607-Ag-1 | interferon, lambda receptor 1 (IFNLR1) protein |
| ORF Viral Vector | pGMLPm004966 | mouse Ifnlr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004966 | mouse Ifnlr1 Lentivirus particle |
Target information
| Target ID | GM-IP0077 |
| Target Name | MAGEA4 |
| Gene ID | 4103,17140,710825 |
| Gene Symbol and Synonyms | CT1.4,MAGE-41,Mage-a4,MAGE-X2,MAGE4,MAGE4A,MAGE4B,MAGEA4 |
| Uniprot Accession | P43358 |
| Uniprot Entry Name | MAGA4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000147381 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: IFNLR1, gene name: IFNLR1, also named as CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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