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Anti-IGSF8/ CD316/ CD81P3 monoclonal antibody
Anti-IGSF8/ CD316/ CD81P3 antibody for FACS & in-vivo assay
Go to IGSF8/IGSF8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0616-Ab-1/ GM-Tg-hg-MP0616-Ab-2 | Anti-Human IGSF8 monoclonal antibody | Human |
| GM-Tg-rg-MP0616-Ab-1/ GM-Tg-rg-MP0616-Ab-2 | Anti-Rat IGSF8 monoclonal antibody | Rat |
| GM-Tg-mg-MP0616-Ab-1/ GM-Tg-mg-MP0616-Ab-2 | Anti-Mouse IGSF8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0616-Ab-1/ GM-Tg-cynog-MP0616-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGSF8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0616-Ab-1/ GM-Tg-felg-MP0616-Ab-2 | Anti-Feline IGSF8 monoclonal antibody | Feline |
| GM-Tg-cang-MP0616-Ab-1/ GM-Tg-cang-MP0616-Ab-2 | Anti-Canine IGSF8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0616-Ab-1/ GM-Tg-bovg-MP0616-Ab-2 | Anti-Bovine IGSF8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0616-Ab-1/ GM-Tg-equg-MP0616-Ab-2 | Anti-Equine IGSF8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0616-Ab-1/ GM-Tg-hg-MP0616-Ab-2; GM-Tg-rg-MP0616-Ab-1/ GM-Tg-rg-MP0616-Ab-2; GM-Tg-mg-MP0616-Ab-1/ GM-Tg-mg-MP0616-Ab-2; GM-Tg-cynog-MP0616-Ab-1/ GM-Tg-cynog-MP0616-Ab-2; GM-Tg-felg-MP0616-Ab-1/ GM-Tg-felg-MP0616-Ab-2; GM-Tg-cang-MP0616-Ab-1/ GM-Tg-cang-MP0616-Ab-2; GM-Tg-bovg-MP0616-Ab-1/ GM-Tg-bovg-MP0616-Ab-2; GM-Tg-equg-MP0616-Ab-1/ GM-Tg-equg-MP0616-Ab-2 |
| Products Name | Anti-IGSF8 monoclonal antibody |
| Format | mab |
| Target Name | IGSF8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGSF8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IGSF8/ CD316/ CD81P3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000337 | Human IGSF8 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000337 | Human IGSF8 Adenovirus particle |
Target information
| Target ID | GM-MP0616 |
| Target Name | IGSF8 |
| Gene ID | 93185,140559,304979,720186,100855523,101097041,519266,100058209 |
| Gene Symbol and Synonyms | CD316,CD81P3,ES™34,EWI-2,EWI2,IGSF8,KCT-4,LIR-D1,PGRL |
| Uniprot Accession | Q969P0 |
| Uniprot Entry Name | IGSF8_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000162729 |
| Target Classification | N/A |
The target: IGSF8, gene name: IGSF8, also named as CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL. This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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