Anti-IL18R/ IL18R1/ CD218a monoclonal antibody

Anti-IL18R/ IL18R1/ CD218a antibody for FACS & in-vivo assay

Target products collectionGo to IL18R1/IL18R1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0619-Ab-1/ GM-Tg-hg-MP0619-Ab-2Anti-Human IL18R1 monoclonal antibodyHuman
GM-Tg-rg-MP0619-Ab-1/ GM-Tg-rg-MP0619-Ab-2Anti-Rat IL18R1 monoclonal antibodyRat
GM-Tg-mg-MP0619-Ab-1/ GM-Tg-mg-MP0619-Ab-2Anti-Mouse IL18R1 monoclonal antibodyMouse
GM-Tg-cynog-MP0619-Ab-1/ GM-Tg-cynog-MP0619-Ab-2Anti-Cynomolgus/ Rhesus macaque IL18R1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0619-Ab-1/ GM-Tg-felg-MP0619-Ab-2Anti-Feline IL18R1 monoclonal antibodyFeline
GM-Tg-cang-MP0619-Ab-1/ GM-Tg-cang-MP0619-Ab-2Anti-Canine IL18R1 monoclonal antibodyCanine
GM-Tg-bovg-MP0619-Ab-1/ GM-Tg-bovg-MP0619-Ab-2Anti-Bovine IL18R1 monoclonal antibodyBovine
GM-Tg-equg-MP0619-Ab-1/ GM-Tg-equg-MP0619-Ab-2Anti-Equine IL18R1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0619-Ab-1/ GM-Tg-hg-MP0619-Ab-2; GM-Tg-rg-MP0619-Ab-1/ GM-Tg-rg-MP0619-Ab-2;
GM-Tg-mg-MP0619-Ab-1/ GM-Tg-mg-MP0619-Ab-2; GM-Tg-cynog-MP0619-Ab-1/ GM-Tg-cynog-MP0619-Ab-2;
GM-Tg-felg-MP0619-Ab-1/ GM-Tg-felg-MP0619-Ab-2; GM-Tg-cang-MP0619-Ab-1/ GM-Tg-cang-MP0619-Ab-2;
GM-Tg-bovg-MP0619-Ab-1/ GM-Tg-bovg-MP0619-Ab-2; GM-Tg-equg-MP0619-Ab-1/ GM-Tg-equg-MP0619-Ab-2
Products NameAnti-IL18R1 monoclonal antibody
Formatmab
Target NameIL18R1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL18R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IL18R/ IL18R1/ CD218a VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0619-Ag-1interleukin 18 receptor 1 (IL18R1) protein
    ORF Viral VectorpGMLPm002056mouse Il18r1 Lentivirus plasmid
    ORF Viral VectorvGMLPm002056mouse Il18r1 Lentivirus particle


    Target information

    Target IDGM-MP0619
    Target NameIL18R1
    Gene ID8809,16182,301365,100426588,611438,493938,407221,100058269
    Gene Symbol and SynonymsCD218a,CDw218a,IL-18R-alpha,IL-18Ra,IL-18Ralpha,IL-1Rrp,IL18R1,IL18RA,Il18ralpha,IL18Ralpha2,IL1RRP
    Uniprot AccessionQ13478
    Uniprot Entry NameIL18R_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000115604
    Target ClassificationN/A

    The target: IL18R1, gene name: IL18R1, also named as CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.