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Anti-ILRL1/ IL1RL1/ DER4 monoclonal antibody
Anti-ILRL1/ IL1RL1/ DER4 antibody for FACS & in-vivo assay
Go to IL1RL1/IL1RL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0622-Ab-1/ GM-Tg-hg-MP0622-Ab-2 | Anti-Human IL1RL1 monoclonal antibody | Human |
| GM-Tg-rg-MP0622-Ab-1/ GM-Tg-rg-MP0622-Ab-2 | Anti-Rat IL1RL1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0622-Ab-1/ GM-Tg-mg-MP0622-Ab-2 | Anti-Mouse IL1RL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0622-Ab-1/ GM-Tg-cynog-MP0622-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL1RL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0622-Ab-1/ GM-Tg-felg-MP0622-Ab-2 | Anti-Feline IL1RL1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0622-Ab-1/ GM-Tg-cang-MP0622-Ab-2 | Anti-Canine IL1RL1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0622-Ab-1/ GM-Tg-bovg-MP0622-Ab-2 | Anti-Bovine IL1RL1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0622-Ab-1/ GM-Tg-equg-MP0622-Ab-2 | Anti-Equine IL1RL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0622-Ab-1/ GM-Tg-hg-MP0622-Ab-2; GM-Tg-rg-MP0622-Ab-1/ GM-Tg-rg-MP0622-Ab-2; GM-Tg-mg-MP0622-Ab-1/ GM-Tg-mg-MP0622-Ab-2; GM-Tg-cynog-MP0622-Ab-1/ GM-Tg-cynog-MP0622-Ab-2; GM-Tg-felg-MP0622-Ab-1/ GM-Tg-felg-MP0622-Ab-2; GM-Tg-cang-MP0622-Ab-1/ GM-Tg-cang-MP0622-Ab-2; GM-Tg-bovg-MP0622-Ab-1/ GM-Tg-bovg-MP0622-Ab-2; GM-Tg-equg-MP0622-Ab-1/ GM-Tg-equg-MP0622-Ab-2 |
| Products Name | Anti-IL1RL1 monoclonal antibody |
| Format | mab |
| Target Name | IL1RL1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL1RL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-033 | Pre-Made Astegolimab biosimilar, Whole mAb, Anti-IL1RL1/ST2 Antibody: Anti-DER4/FIT-1/IL33R/T1 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-340 | Pre-Made Melrilimab biosimilar, Whole mAb, Anti-IL1RL1/ST2 Antibody: Anti-DER4/FIT-1/IL33R/T1 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species ILRL1/ IL1RL1/ DER4 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0622-Ag-1 | interleukin 1 receptor-like 1 (IL1RL1) protein |
| ORF Viral Vector | pGMLP003795 | human IL1RL1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003795 | human IL1RL1 Lentivirus particle |
| ORF Viral Vector | pGMAAV000249 | house mouse Il1rl1 AAV plasmid |
| ORF Viral Vector | vGMAAV000249 | house mouse Il1rl1 AAV particle |
Target information
| Target ID | GM-MP0622 |
| Target Name | IL1RL1 |
| Gene ID | 9173,17082,25556,711893,611442,101080448,520709,100058357 |
| Gene Symbol and Synonyms | DER4,FIT-1,FIT1,IL1RL1,IL33R,Ly84,ST2,St2-rs1,ST2L,ST2V,T1,T1/ST2 |
| Uniprot Accession | Q01638,Q62611 |
| Uniprot Entry Name | ILRL1_HUMAN,ILRL1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000115602 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IL1RL1, gene name: IL1RL1, also named as DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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