Anti-PI5PA/ INPP5J/ INPP5 monoclonal antibody

Anti-PI5PA/ INPP5J/ INPP5 antibody for FACS & in-vivo assay

Target products collectionGo to INPP5J/INPP5J products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0630-Ab-1/ GM-Tg-hg-MP0630-Ab-2Anti-Human INPP5J monoclonal antibodyHuman
GM-Tg-rg-MP0630-Ab-1/ GM-Tg-rg-MP0630-Ab-2Anti-Rat INPP5J monoclonal antibodyRat
GM-Tg-mg-MP0630-Ab-1/ GM-Tg-mg-MP0630-Ab-2Anti-Mouse INPP5J monoclonal antibodyMouse
GM-Tg-cynog-MP0630-Ab-1/ GM-Tg-cynog-MP0630-Ab-2Anti-Cynomolgus/ Rhesus macaque INPP5J monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0630-Ab-1/ GM-Tg-felg-MP0630-Ab-2Anti-Feline INPP5J monoclonal antibodyFeline
GM-Tg-cang-MP0630-Ab-1/ GM-Tg-cang-MP0630-Ab-2Anti-Canine INPP5J monoclonal antibodyCanine
GM-Tg-bovg-MP0630-Ab-1/ GM-Tg-bovg-MP0630-Ab-2Anti-Bovine INPP5J monoclonal antibodyBovine
GM-Tg-equg-MP0630-Ab-1/ GM-Tg-equg-MP0630-Ab-2Anti-Equine INPP5J monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0630-Ab-1/ GM-Tg-hg-MP0630-Ab-2; GM-Tg-rg-MP0630-Ab-1/ GM-Tg-rg-MP0630-Ab-2;
GM-Tg-mg-MP0630-Ab-1/ GM-Tg-mg-MP0630-Ab-2; GM-Tg-cynog-MP0630-Ab-1/ GM-Tg-cynog-MP0630-Ab-2;
GM-Tg-felg-MP0630-Ab-1/ GM-Tg-felg-MP0630-Ab-2; GM-Tg-cang-MP0630-Ab-1/ GM-Tg-cang-MP0630-Ab-2;
GM-Tg-bovg-MP0630-Ab-1/ GM-Tg-bovg-MP0630-Ab-2; GM-Tg-equg-MP0630-Ab-1/ GM-Tg-equg-MP0630-Ab-2
Products NameAnti-INPP5J monoclonal antibody
Formatmab
Target NameINPP5J
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-INPP5J benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PI5PA/ INPP5J/ INPP5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0630
    Target NameINPP5J
    Gene ID27124,170835,171088,718308,486360,101095688,514307,100058547
    Gene Symbol and SynonymsInpp,INPP5,INPP5J,PIB5PA,PIPP
    Uniprot AccessionQ15735,Q9JMC1
    Uniprot Entry NamePI5PA_HUMAN,PI5PA_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000185133
    Target ClassificationN/A

    The target: INPP5J, gene name: INPP5J, also named as INPP5, PIB5PA, PIPP. Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.