Anti-ITA10/ ITGA10/ PRO827 monoclonal antibody

Anti-ITA10/ ITGA10/ PRO827 antibody for FACS & in-vivo assay

Target products collectionGo to ITGA10/ITGA10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0633-Ab-1/ GM-Tg-hg-MP0633-Ab-2Anti-Human ITGA10 monoclonal antibodyHuman
GM-Tg-rg-MP0633-Ab-1/ GM-Tg-rg-MP0633-Ab-2Anti-Rat ITGA10 monoclonal antibodyRat
GM-Tg-mg-MP0633-Ab-1/ GM-Tg-mg-MP0633-Ab-2Anti-Mouse ITGA10 monoclonal antibodyMouse
GM-Tg-cynog-MP0633-Ab-1/ GM-Tg-cynog-MP0633-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGA10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0633-Ab-1/ GM-Tg-felg-MP0633-Ab-2Anti-Feline ITGA10 monoclonal antibodyFeline
GM-Tg-cang-MP0633-Ab-1/ GM-Tg-cang-MP0633-Ab-2Anti-Canine ITGA10 monoclonal antibodyCanine
GM-Tg-bovg-MP0633-Ab-1/ GM-Tg-bovg-MP0633-Ab-2Anti-Bovine ITGA10 monoclonal antibodyBovine
GM-Tg-equg-MP0633-Ab-1/ GM-Tg-equg-MP0633-Ab-2Anti-Equine ITGA10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0633-Ab-1/ GM-Tg-hg-MP0633-Ab-2; GM-Tg-rg-MP0633-Ab-1/ GM-Tg-rg-MP0633-Ab-2;
GM-Tg-mg-MP0633-Ab-1/ GM-Tg-mg-MP0633-Ab-2; GM-Tg-cynog-MP0633-Ab-1/ GM-Tg-cynog-MP0633-Ab-2;
GM-Tg-felg-MP0633-Ab-1/ GM-Tg-felg-MP0633-Ab-2; GM-Tg-cang-MP0633-Ab-1/ GM-Tg-cang-MP0633-Ab-2;
GM-Tg-bovg-MP0633-Ab-1/ GM-Tg-bovg-MP0633-Ab-2; GM-Tg-equg-MP0633-Ab-1/ GM-Tg-equg-MP0633-Ab-2
Products NameAnti-ITGA10 monoclonal antibody
Formatmab
Target NameITGA10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGA10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ITA10/ ITGA10/ PRO827 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0633
    Target NameITGA10
    Gene ID8515,213119,310683,100428484,608287,101097997,506526,100065205
    Gene Symbol and SynonymsA630048L14,ITGA10,PRO827
    Uniprot AccessionO75578
    Uniprot Entry NameITA10_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000143127
    Target ClassificationN/A

    The target: ITGA10, gene name: ITGA10, also named as PRO827. Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.