Anti-ITAD/ ITGAD/ ADB2 monoclonal antibody

Anti-ITAD/ ITGAD/ ADB2 antibody for FACS & in-vivo assay

Target products collectionGo to ITGAD/ITGAD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0637-Ab-1/ GM-Tg-hg-MP0637-Ab-2Anti-Human ITGAD monoclonal antibodyHuman
GM-Tg-rg-MP0637-Ab-1/ GM-Tg-rg-MP0637-Ab-2Anti-Rat ITGAD monoclonal antibodyRat
GM-Tg-mg-MP0637-Ab-1/ GM-Tg-mg-MP0637-Ab-2Anti-Mouse ITGAD monoclonal antibodyMouse
GM-Tg-cynog-MP0637-Ab-1/ GM-Tg-cynog-MP0637-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGAD monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0637-Ab-1/ GM-Tg-felg-MP0637-Ab-2Anti-Feline ITGAD monoclonal antibodyFeline
GM-Tg-cang-MP0637-Ab-1/ GM-Tg-cang-MP0637-Ab-2Anti-Canine ITGAD monoclonal antibodyCanine
GM-Tg-bovg-MP0637-Ab-1/ GM-Tg-bovg-MP0637-Ab-2Anti-Bovine ITGAD monoclonal antibodyBovine
GM-Tg-equg-MP0637-Ab-1/ GM-Tg-equg-MP0637-Ab-2Anti-Equine ITGAD monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0637-Ab-1/ GM-Tg-hg-MP0637-Ab-2; GM-Tg-rg-MP0637-Ab-1/ GM-Tg-rg-MP0637-Ab-2;
GM-Tg-mg-MP0637-Ab-1/ GM-Tg-mg-MP0637-Ab-2; GM-Tg-cynog-MP0637-Ab-1/ GM-Tg-cynog-MP0637-Ab-2;
GM-Tg-felg-MP0637-Ab-1/ GM-Tg-felg-MP0637-Ab-2; GM-Tg-cang-MP0637-Ab-1/ GM-Tg-cang-MP0637-Ab-2;
GM-Tg-bovg-MP0637-Ab-1/ GM-Tg-bovg-MP0637-Ab-2; GM-Tg-equg-MP0637-Ab-1/ GM-Tg-equg-MP0637-Ab-2
Products NameAnti-ITGAD monoclonal antibody
Formatmab
Target NameITGAD
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGAD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ITAD/ ITGAD/ ADB2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0637
    Target NameITGAD
    Gene ID3681,381924,714931,105261308,514056,100064753
    Gene Symbol and SynonymsADB2,CD11D,ITGAD
    Uniprot AccessionQ13349
    Uniprot Entry NameITAD_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000156886
    Target ClassificationN/A

    The target: ITGAD, gene name: ITGAD, also named as ADB2, CD11D. This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.