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Anti-ITAX/ ITGAX/ CD11C monoclonal antibody
Anti-ITAX/ ITGAX/ CD11C antibody for FACS & in-vivo assay
Go to ITGAX/ITGAX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0638-Ab-1/ GM-Tg-hg-MP0638-Ab-2 | Anti-Human ITGAX monoclonal antibody | Human |
| GM-Tg-rg-MP0638-Ab-1/ GM-Tg-rg-MP0638-Ab-2 | Anti-Rat ITGAX monoclonal antibody | Rat |
| GM-Tg-mg-MP0638-Ab-1/ GM-Tg-mg-MP0638-Ab-2 | Anti-Mouse ITGAX monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0638-Ab-1/ GM-Tg-cynog-MP0638-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ITGAX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0638-Ab-1/ GM-Tg-felg-MP0638-Ab-2 | Anti-Feline ITGAX monoclonal antibody | Feline |
| GM-Tg-cang-MP0638-Ab-1/ GM-Tg-cang-MP0638-Ab-2 | Anti-Canine ITGAX monoclonal antibody | Canine |
| GM-Tg-bovg-MP0638-Ab-1/ GM-Tg-bovg-MP0638-Ab-2 | Anti-Bovine ITGAX monoclonal antibody | Bovine |
| GM-Tg-equg-MP0638-Ab-1/ GM-Tg-equg-MP0638-Ab-2 | Anti-Equine ITGAX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0638-Ab-1/ GM-Tg-hg-MP0638-Ab-2; GM-Tg-rg-MP0638-Ab-1/ GM-Tg-rg-MP0638-Ab-2; GM-Tg-mg-MP0638-Ab-1/ GM-Tg-mg-MP0638-Ab-2; GM-Tg-cynog-MP0638-Ab-1/ GM-Tg-cynog-MP0638-Ab-2; GM-Tg-felg-MP0638-Ab-1/ GM-Tg-felg-MP0638-Ab-2; GM-Tg-cang-MP0638-Ab-1/ GM-Tg-cang-MP0638-Ab-2; GM-Tg-bovg-MP0638-Ab-1/ GM-Tg-bovg-MP0638-Ab-2; GM-Tg-equg-MP0638-Ab-1/ GM-Tg-equg-MP0638-Ab-2 |
| Products Name | Anti-ITGAX monoclonal antibody |
| Format | mab |
| Target Name | ITGAX |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ITGAX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ITAX/ ITGAX/ CD11C VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0638 |
| Target Name | ITGAX |
| Gene ID | 3687,16411,499271,100427850,489929,101087698,101904063,100064779 |
| Gene Symbol and Synonyms | CD11C,Cr4,ITGAX,N418,RGD1561123,SLEB6 |
| Uniprot Accession | P20702 |
| Uniprot Entry Name | ITAX_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000140678 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ITGAX, gene name: ITGAX, also named as CD11C, SLEB6. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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