Anti-I™2A/ BRICD2A/ E25A monoclonal antibody

Anti-I™2A/ BRICD2A/ E25A antibody for FACS & in-vivo assay

Target products collectionGo to I™2A/I™2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0640-Ab-1/ GM-Tg-hg-MP0640-Ab-2Anti-Human I™2A monoclonal antibodyHuman
GM-Tg-rg-MP0640-Ab-1/ GM-Tg-rg-MP0640-Ab-2Anti-Rat I™2A monoclonal antibodyRat
GM-Tg-mg-MP0640-Ab-1/ GM-Tg-mg-MP0640-Ab-2Anti-Mouse I™2A monoclonal antibodyMouse
GM-Tg-cynog-MP0640-Ab-1/ GM-Tg-cynog-MP0640-Ab-2Anti-Cynomolgus/ Rhesus macaque I™2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0640-Ab-1/ GM-Tg-felg-MP0640-Ab-2Anti-Feline I™2A monoclonal antibodyFeline
GM-Tg-cang-MP0640-Ab-1/ GM-Tg-cang-MP0640-Ab-2Anti-Canine I™2A monoclonal antibodyCanine
GM-Tg-bovg-MP0640-Ab-1/ GM-Tg-bovg-MP0640-Ab-2Anti-Bovine I™2A monoclonal antibodyBovine
GM-Tg-equg-MP0640-Ab-1/ GM-Tg-equg-MP0640-Ab-2Anti-Equine I™2A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0640-Ab-1/ GM-Tg-hg-MP0640-Ab-2; GM-Tg-rg-MP0640-Ab-1/ GM-Tg-rg-MP0640-Ab-2;
GM-Tg-mg-MP0640-Ab-1/ GM-Tg-mg-MP0640-Ab-2; GM-Tg-cynog-MP0640-Ab-1/ GM-Tg-cynog-MP0640-Ab-2;
GM-Tg-felg-MP0640-Ab-1/ GM-Tg-felg-MP0640-Ab-2; GM-Tg-cang-MP0640-Ab-1/ GM-Tg-cang-MP0640-Ab-2;
GM-Tg-bovg-MP0640-Ab-1/ GM-Tg-bovg-MP0640-Ab-2; GM-Tg-equg-MP0640-Ab-1/ GM-Tg-equg-MP0640-Ab-2
Products NameAnti-I™2A monoclonal antibody
Formatmab
Target NameI™2A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-I™2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species I™2A/ BRICD2A/ E25A VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004361human I™2A Lentivirus particle
    ORF Viral VectorpGMLP004361human I™2A Lentivirus plasmid
    ORF Viral VectorpGMLPm003293mouse Itm2a Lentivirus plasmid
    ORF Viral VectorvGMLPm003293mouse Itm2a Lentivirus particle


    Target information

    Target IDGM-MP0640
    Target NameI™2A
    Gene ID9452,16431,317218,708039,101088221,100299798
    Gene Symbol and SynonymsBRICD2A,E25,E25A,Itm2,I™2A
    Uniprot AccessionO43736
    Uniprot Entry NameI™2A_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000078596
    Target ClassificationN/A

    The target: I™2A, gene name: I™2A, also named as BRICD2A, E25A. This gene encodes a type II membrane protein that belongs to the I™2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.