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Anti-I™2B/ ABRI/ BRI monoclonal antibody
Anti-I™2B/ ABRI/ BRI antibody for FACS & in-vivo assay
Go to I™2B/I™2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0641-Ab-1/ GM-Tg-hg-MP0641-Ab-2 | Anti-Human I™2B monoclonal antibody | Human |
| GM-Tg-rg-MP0641-Ab-1/ GM-Tg-rg-MP0641-Ab-2 | Anti-Rat I™2B monoclonal antibody | Rat |
| GM-Tg-mg-MP0641-Ab-1/ GM-Tg-mg-MP0641-Ab-2 | Anti-Mouse I™2B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0641-Ab-1/ GM-Tg-cynog-MP0641-Ab-2 | Anti-Cynomolgus/ Rhesus macaque I™2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0641-Ab-1/ GM-Tg-felg-MP0641-Ab-2 | Anti-Feline I™2B monoclonal antibody | Feline |
| GM-Tg-cang-MP0641-Ab-1/ GM-Tg-cang-MP0641-Ab-2 | Anti-Canine I™2B monoclonal antibody | Canine |
| GM-Tg-bovg-MP0641-Ab-1/ GM-Tg-bovg-MP0641-Ab-2 | Anti-Bovine I™2B monoclonal antibody | Bovine |
| GM-Tg-equg-MP0641-Ab-1/ GM-Tg-equg-MP0641-Ab-2 | Anti-Equine I™2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0641-Ab-1/ GM-Tg-hg-MP0641-Ab-2; GM-Tg-rg-MP0641-Ab-1/ GM-Tg-rg-MP0641-Ab-2; GM-Tg-mg-MP0641-Ab-1/ GM-Tg-mg-MP0641-Ab-2; GM-Tg-cynog-MP0641-Ab-1/ GM-Tg-cynog-MP0641-Ab-2; GM-Tg-felg-MP0641-Ab-1/ GM-Tg-felg-MP0641-Ab-2; GM-Tg-cang-MP0641-Ab-1/ GM-Tg-cang-MP0641-Ab-2; GM-Tg-bovg-MP0641-Ab-1/ GM-Tg-bovg-MP0641-Ab-2; GM-Tg-equg-MP0641-Ab-1/ GM-Tg-equg-MP0641-Ab-2 |
| Products Name | Anti-I™2B monoclonal antibody |
| Format | mab |
| Target Name | I™2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-I™2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I™2B/ ABRI/ BRI VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0641 |
| Target Name | I™2B |
| Gene ID | 9445,16432,290364,709896,476916,101101607,510575,100050288 |
| Gene Symbol and Synonyms | ABRI,BRI,BRI2,BRICD2B,D14Sel6,E25B,E25BMM,E3-16,FBD,imBRI2,I™2B,RDGCA |
| Uniprot Accession | Q9Y287,Q5XIE8,Q3T0P7 |
| Uniprot Entry Name | I™2B_HUMAN,I™2B_RAT,I™2B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136156 |
| Target Classification | N/A |
The target: I™2B, gene name: I™2B, also named as ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2. Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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