Anti-ITSN1/ ITSN/ SH3D1A monoclonal antibody

Anti-ITSN1/ ITSN/ SH3D1A antibody for FACS & in-vivo assay

Target products collectionGo to ITSN1/ITSN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0644-Ab-1/ GM-Tg-hg-MP0644-Ab-2Anti-Human ITSN1 monoclonal antibodyHuman
GM-Tg-rg-MP0644-Ab-1/ GM-Tg-rg-MP0644-Ab-2Anti-Rat ITSN1 monoclonal antibodyRat
GM-Tg-mg-MP0644-Ab-1/ GM-Tg-mg-MP0644-Ab-2Anti-Mouse ITSN1 monoclonal antibodyMouse
GM-Tg-cynog-MP0644-Ab-1/ GM-Tg-cynog-MP0644-Ab-2Anti-Cynomolgus/ Rhesus macaque ITSN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0644-Ab-1/ GM-Tg-felg-MP0644-Ab-2Anti-Feline ITSN1 monoclonal antibodyFeline
GM-Tg-cang-MP0644-Ab-1/ GM-Tg-cang-MP0644-Ab-2Anti-Canine ITSN1 monoclonal antibodyCanine
GM-Tg-bovg-MP0644-Ab-1/ GM-Tg-bovg-MP0644-Ab-2Anti-Bovine ITSN1 monoclonal antibodyBovine
GM-Tg-equg-MP0644-Ab-1/ GM-Tg-equg-MP0644-Ab-2Anti-Equine ITSN1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0644-Ab-1/ GM-Tg-hg-MP0644-Ab-2; GM-Tg-rg-MP0644-Ab-1/ GM-Tg-rg-MP0644-Ab-2;
GM-Tg-mg-MP0644-Ab-1/ GM-Tg-mg-MP0644-Ab-2; GM-Tg-cynog-MP0644-Ab-1/ GM-Tg-cynog-MP0644-Ab-2;
GM-Tg-felg-MP0644-Ab-1/ GM-Tg-felg-MP0644-Ab-2; GM-Tg-cang-MP0644-Ab-1/ GM-Tg-cang-MP0644-Ab-2;
GM-Tg-bovg-MP0644-Ab-1/ GM-Tg-bovg-MP0644-Ab-2; GM-Tg-equg-MP0644-Ab-1/ GM-Tg-equg-MP0644-Ab-2
Products NameAnti-ITSN1 monoclonal antibody
Formatmab
Target NameITSN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITSN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ITSN1/ ITSN/ SH3D1A VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0644
    Target NameITSN1
    Gene ID6453,16443,29491,698606,478409,101087514,510879,100062926
    Gene Symbol and SynonymsEhsh1,Ese1,ITSN,ITSN1,SH3D1A,SH3P17
    Uniprot AccessionQ15811,Q9WVE9
    Uniprot Entry NameITSN1_HUMAN,ITSN1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000205726
    Target ClassificationN/A

    The target: ITSN1, gene name: ITSN1, also named as ITSN, SH3D1A, SH3P17. The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.