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Anti-IYD1/ IYD/ C6orf71 monoclonal antibody
Anti-IYD1/ IYD/ C6orf71 antibody for FACS & in-vivo assay
Go to IYD/IYD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0645-Ab-1/ GM-Tg-hg-MP0645-Ab-2 | Anti-Human IYD monoclonal antibody | Human |
| GM-Tg-rg-MP0645-Ab-1/ GM-Tg-rg-MP0645-Ab-2 | Anti-Rat IYD monoclonal antibody | Rat |
| GM-Tg-mg-MP0645-Ab-1/ GM-Tg-mg-MP0645-Ab-2 | Anti-Mouse IYD monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0645-Ab-1/ GM-Tg-cynog-MP0645-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IYD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0645-Ab-1/ GM-Tg-felg-MP0645-Ab-2 | Anti-Feline IYD monoclonal antibody | Feline |
| GM-Tg-cang-MP0645-Ab-1/ GM-Tg-cang-MP0645-Ab-2 | Anti-Canine IYD monoclonal antibody | Canine |
| GM-Tg-bovg-MP0645-Ab-1/ GM-Tg-bovg-MP0645-Ab-2 | Anti-Bovine IYD monoclonal antibody | Bovine |
| GM-Tg-equg-MP0645-Ab-1/ GM-Tg-equg-MP0645-Ab-2 | Anti-Equine IYD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0645-Ab-1/ GM-Tg-hg-MP0645-Ab-2; GM-Tg-rg-MP0645-Ab-1/ GM-Tg-rg-MP0645-Ab-2; GM-Tg-mg-MP0645-Ab-1/ GM-Tg-mg-MP0645-Ab-2; GM-Tg-cynog-MP0645-Ab-1/ GM-Tg-cynog-MP0645-Ab-2; GM-Tg-felg-MP0645-Ab-1/ GM-Tg-felg-MP0645-Ab-2; GM-Tg-cang-MP0645-Ab-1/ GM-Tg-cang-MP0645-Ab-2; GM-Tg-bovg-MP0645-Ab-1/ GM-Tg-bovg-MP0645-Ab-2; GM-Tg-equg-MP0645-Ab-1/ GM-Tg-equg-MP0645-Ab-2 |
| Products Name | Anti-IYD monoclonal antibody |
| Format | mab |
| Target Name | IYD |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IYD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IYD1/ IYD/ C6orf71 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0645 |
| Target Name | IYD |
| Gene ID | 389434,70337,308129,705471,476244,101100136,534110,100147582 |
| Gene Symbol and Synonyms | 0610009A07Rik,C6orf71,DEHAL1,IYD,IYD-1,RGD1309288,TDH4 |
| Uniprot Accession | Q6PHW0,Q5BK17 |
| Uniprot Entry Name | IYD1_HUMAN,IYD1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000009765 |
| Target Classification | N/A |
The target: IYD, gene name: IYD, also named as C6orf71, DEHAL1-1, TDH4, IYD. This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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