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Anti-JAM3/ JAM-2/ JAM-3 monoclonal antibody
Anti-JAM3/ JAM-2/ JAM-3 antibody for FACS & in-vivo assay
Go to JAM3/JAM3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0650-Ab-1/ GM-Tg-hg-MP0650-Ab-2 | Anti-Human JAM3 monoclonal antibody | Human |
| GM-Tg-rg-MP0650-Ab-1/ GM-Tg-rg-MP0650-Ab-2 | Anti-Rat JAM3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0650-Ab-1/ GM-Tg-mg-MP0650-Ab-2 | Anti-Mouse JAM3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0650-Ab-1/ GM-Tg-cynog-MP0650-Ab-2 | Anti-Cynomolgus/ Rhesus macaque JAM3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0650-Ab-1/ GM-Tg-felg-MP0650-Ab-2 | Anti-Feline JAM3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0650-Ab-1/ GM-Tg-cang-MP0650-Ab-2 | Anti-Canine JAM3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0650-Ab-1/ GM-Tg-bovg-MP0650-Ab-2 | Anti-Bovine JAM3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0650-Ab-1/ GM-Tg-equg-MP0650-Ab-2 | Anti-Equine JAM3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0650-Ab-1/ GM-Tg-hg-MP0650-Ab-2; GM-Tg-rg-MP0650-Ab-1/ GM-Tg-rg-MP0650-Ab-2; GM-Tg-mg-MP0650-Ab-1/ GM-Tg-mg-MP0650-Ab-2; GM-Tg-cynog-MP0650-Ab-1/ GM-Tg-cynog-MP0650-Ab-2; GM-Tg-felg-MP0650-Ab-1/ GM-Tg-felg-MP0650-Ab-2; GM-Tg-cang-MP0650-Ab-1/ GM-Tg-cang-MP0650-Ab-2; GM-Tg-bovg-MP0650-Ab-1/ GM-Tg-bovg-MP0650-Ab-2; GM-Tg-equg-MP0650-Ab-1/ GM-Tg-equg-MP0650-Ab-2 |
| Products Name | Anti-JAM3 monoclonal antibody |
| Format | mab |
| Target Name | JAM3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-JAM3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species JAM3/ JAM-2/ JAM-3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004460 | human JAM3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004460 | human JAM3 Lentivirus particle |
| ORF Viral Vector | pGMLPm001133 | mouse Jam3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001133 | mouse Jam3 Lentivirus particle |
Target information
| Target ID | GM-MP0650 |
| Target Name | JAM3 |
| Gene ID | 83700,83964,315509,694042,489271,101097016,513412,100072872 |
| Gene Symbol and Synonyms | 1110002N23Rik,JAM-2,JAM-3,JAM-C,JAM3,JAMC,Jcam3 |
| Uniprot Accession | Q9BX67,Q68FQ2 |
| Uniprot Entry Name | JAM3_HUMAN,JAM3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166086 |
| Target Classification | N/A |
The target: JAM3, gene name: JAM3, also named as JAM-2, JAM-3, JAM-C, JAMC. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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