Anti-JPH1/ CMT2K/ JP-1 monoclonal antibody

Anti-JPH1/ CMT2K/ JP-1 antibody for FACS & in-vivo assay

Target products collectionGo to JPH1/JPH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0651-Ab-1/ GM-Tg-hg-MP0651-Ab-2Anti-Human JPH1 monoclonal antibodyHuman
GM-Tg-rg-MP0651-Ab-1/ GM-Tg-rg-MP0651-Ab-2Anti-Rat JPH1 monoclonal antibodyRat
GM-Tg-mg-MP0651-Ab-1/ GM-Tg-mg-MP0651-Ab-2Anti-Mouse JPH1 monoclonal antibodyMouse
GM-Tg-cynog-MP0651-Ab-1/ GM-Tg-cynog-MP0651-Ab-2Anti-Cynomolgus/ Rhesus macaque JPH1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0651-Ab-1/ GM-Tg-felg-MP0651-Ab-2Anti-Feline JPH1 monoclonal antibodyFeline
GM-Tg-cang-MP0651-Ab-1/ GM-Tg-cang-MP0651-Ab-2Anti-Canine JPH1 monoclonal antibodyCanine
GM-Tg-bovg-MP0651-Ab-1/ GM-Tg-bovg-MP0651-Ab-2Anti-Bovine JPH1 monoclonal antibodyBovine
GM-Tg-equg-MP0651-Ab-1/ GM-Tg-equg-MP0651-Ab-2Anti-Equine JPH1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0651-Ab-1/ GM-Tg-hg-MP0651-Ab-2; GM-Tg-rg-MP0651-Ab-1/ GM-Tg-rg-MP0651-Ab-2;
GM-Tg-mg-MP0651-Ab-1/ GM-Tg-mg-MP0651-Ab-2; GM-Tg-cynog-MP0651-Ab-1/ GM-Tg-cynog-MP0651-Ab-2;
GM-Tg-felg-MP0651-Ab-1/ GM-Tg-felg-MP0651-Ab-2; GM-Tg-cang-MP0651-Ab-1/ GM-Tg-cang-MP0651-Ab-2;
GM-Tg-bovg-MP0651-Ab-1/ GM-Tg-bovg-MP0651-Ab-2; GM-Tg-equg-MP0651-Ab-1/ GM-Tg-equg-MP0651-Ab-2
Products NameAnti-JPH1 monoclonal antibody
Formatmab
Target NameJPH1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-JPH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species JPH1/ CMT2K/ JP-1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0651
    Target NameJPH1
    Gene ID56704,57339,297748,697014,487001,101082124,536811,100051011
    Gene Symbol and SynonymsCMT2K,JP-1,JP1,JPH1
    Uniprot AccessionQ9HDC5
    Uniprot Entry NameJPH1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000104369
    Target ClassificationN/A

    The target: JPH1, gene name: JPH1, also named as CMT2K, JP-1, JP1. Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.