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Anti-KCNH4/ BEC2/ ELK1 monoclonal antibody
Anti-KCNH4/ BEC2/ ELK1 antibody for FACS & in-vivo assay
Go to KCNH4/KCNH4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0663-Ab-1/ GM-Tg-hg-MP0663-Ab-2 | Anti-Human KCNH4 monoclonal antibody | Human |
| GM-Tg-rg-MP0663-Ab-1/ GM-Tg-rg-MP0663-Ab-2 | Anti-Rat KCNH4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0663-Ab-1/ GM-Tg-mg-MP0663-Ab-2 | Anti-Mouse KCNH4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0663-Ab-1/ GM-Tg-cynog-MP0663-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNH4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0663-Ab-1/ GM-Tg-felg-MP0663-Ab-2 | Anti-Feline KCNH4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0663-Ab-1/ GM-Tg-cang-MP0663-Ab-2 | Anti-Canine KCNH4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0663-Ab-1/ GM-Tg-bovg-MP0663-Ab-2 | Anti-Bovine KCNH4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0663-Ab-1/ GM-Tg-equg-MP0663-Ab-2 | Anti-Equine KCNH4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0663-Ab-1/ GM-Tg-hg-MP0663-Ab-2; GM-Tg-rg-MP0663-Ab-1/ GM-Tg-rg-MP0663-Ab-2; GM-Tg-mg-MP0663-Ab-1/ GM-Tg-mg-MP0663-Ab-2; GM-Tg-cynog-MP0663-Ab-1/ GM-Tg-cynog-MP0663-Ab-2; GM-Tg-felg-MP0663-Ab-1/ GM-Tg-felg-MP0663-Ab-2; GM-Tg-cang-MP0663-Ab-1/ GM-Tg-cang-MP0663-Ab-2; GM-Tg-bovg-MP0663-Ab-1/ GM-Tg-bovg-MP0663-Ab-2; GM-Tg-equg-MP0663-Ab-1/ GM-Tg-equg-MP0663-Ab-2 |
| Products Name | Anti-KCNH4 monoclonal antibody |
| Format | mab |
| Target Name | KCNH4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNH4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNH4/ BEC2/ ELK1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0663 |
| Target Name | KCNH4 |
| Gene ID | 23415,380728,114032,100428348,607649,101095210,535907,100146220 |
| Gene Symbol and Synonyms | BEC2,ELK1,KCNH4,Kv12.3 |
| Uniprot Accession | Q9UQ05,Q9R1T9 |
| Uniprot Entry Name | KCNH4_HUMAN,KCNH4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000089558 |
| Target Classification | Ion Channel |
The target: KCNH4, gene name: KCNH4, also named as BEC2, ELK1, Kv12.3. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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