Anti-KCNH6/ ERG-2/ ERG2 monoclonal antibody

Anti-KCNH6/ ERG-2/ ERG2 antibody for FACS & in-vivo assay

Target products collectionGo to KCNH6/KCNH6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0664-Ab-1/ GM-Tg-hg-MP0664-Ab-2Anti-Human KCNH6 monoclonal antibodyHuman
GM-Tg-rg-MP0664-Ab-1/ GM-Tg-rg-MP0664-Ab-2Anti-Rat KCNH6 monoclonal antibodyRat
GM-Tg-mg-MP0664-Ab-1/ GM-Tg-mg-MP0664-Ab-2Anti-Mouse KCNH6 monoclonal antibodyMouse
GM-Tg-cynog-MP0664-Ab-1/ GM-Tg-cynog-MP0664-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNH6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0664-Ab-1/ GM-Tg-felg-MP0664-Ab-2Anti-Feline KCNH6 monoclonal antibodyFeline
GM-Tg-cang-MP0664-Ab-1/ GM-Tg-cang-MP0664-Ab-2Anti-Canine KCNH6 monoclonal antibodyCanine
GM-Tg-bovg-MP0664-Ab-1/ GM-Tg-bovg-MP0664-Ab-2Anti-Bovine KCNH6 monoclonal antibodyBovine
GM-Tg-equg-MP0664-Ab-1/ GM-Tg-equg-MP0664-Ab-2Anti-Equine KCNH6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0664-Ab-1/ GM-Tg-hg-MP0664-Ab-2; GM-Tg-rg-MP0664-Ab-1/ GM-Tg-rg-MP0664-Ab-2;
GM-Tg-mg-MP0664-Ab-1/ GM-Tg-mg-MP0664-Ab-2; GM-Tg-cynog-MP0664-Ab-1/ GM-Tg-cynog-MP0664-Ab-2;
GM-Tg-felg-MP0664-Ab-1/ GM-Tg-felg-MP0664-Ab-2; GM-Tg-cang-MP0664-Ab-1/ GM-Tg-cang-MP0664-Ab-2;
GM-Tg-bovg-MP0664-Ab-1/ GM-Tg-bovg-MP0664-Ab-2; GM-Tg-equg-MP0664-Ab-1/ GM-Tg-equg-MP0664-Ab-2
Products NameAnti-KCNH6 monoclonal antibody
Formatmab
Target NameKCNH6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNH6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNH6/ ERG-2/ ERG2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0664
    Target NameKCNH6
    Gene ID81033,192775,116745,717765,100856219,101083379,527872,100054322
    Gene Symbol and SynonymsERG-2,ERG2,hERG-2,HERG2,KCNH6,Kv11.2,m-erg2
    Uniprot AccessionQ9H252,O54853
    Uniprot Entry NameKCNH6_HUMAN,KCNH6_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000173826
    Target ClassificationIon Channel

    The target: KCNH6, gene name: KCNH6, also named as ERG-2, ERG2, HERG2, Kv11.2, hERG-2. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.