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Anti-KCNH7/ ERG3/ HERG3 monoclonal antibody
Anti-KCNH7/ ERG3/ HERG3 antibody for FACS & in-vivo assay
Go to KCNH7/KCNH7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0665-Ab-1/ GM-Tg-hg-MP0665-Ab-2 | Anti-Human KCNH7 monoclonal antibody | Human |
| GM-Tg-rg-MP0665-Ab-1/ GM-Tg-rg-MP0665-Ab-2 | Anti-Rat KCNH7 monoclonal antibody | Rat |
| GM-Tg-mg-MP0665-Ab-1/ GM-Tg-mg-MP0665-Ab-2 | Anti-Mouse KCNH7 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0665-Ab-1/ GM-Tg-cynog-MP0665-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNH7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0665-Ab-1/ GM-Tg-felg-MP0665-Ab-2 | Anti-Feline KCNH7 monoclonal antibody | Feline |
| GM-Tg-cang-MP0665-Ab-1/ GM-Tg-cang-MP0665-Ab-2 | Anti-Canine KCNH7 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0665-Ab-1/ GM-Tg-bovg-MP0665-Ab-2 | Anti-Bovine KCNH7 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0665-Ab-1/ GM-Tg-equg-MP0665-Ab-2 | Anti-Equine KCNH7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0665-Ab-1/ GM-Tg-hg-MP0665-Ab-2; GM-Tg-rg-MP0665-Ab-1/ GM-Tg-rg-MP0665-Ab-2; GM-Tg-mg-MP0665-Ab-1/ GM-Tg-mg-MP0665-Ab-2; GM-Tg-cynog-MP0665-Ab-1/ GM-Tg-cynog-MP0665-Ab-2; GM-Tg-felg-MP0665-Ab-1/ GM-Tg-felg-MP0665-Ab-2; GM-Tg-cang-MP0665-Ab-1/ GM-Tg-cang-MP0665-Ab-2; GM-Tg-bovg-MP0665-Ab-1/ GM-Tg-bovg-MP0665-Ab-2; GM-Tg-equg-MP0665-Ab-1/ GM-Tg-equg-MP0665-Ab-2 |
| Products Name | Anti-KCNH7 monoclonal antibody |
| Format | mab |
| Target Name | KCNH7 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNH7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNH7/ ERG3/ HERG3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001957 | human KCNH7 Lentivirus particle |
| ORF Viral Vector | pGMLP001957 | human KCNH7 Lentivirus plasmid |
Target information
| Target ID | GM-MP0665 |
| Target Name | KCNH7 |
| Gene ID | 90134,170738,170739,702259,478768,101098320,100051695 |
| Gene Symbol and Synonyms | 9330137I11Rik,ERG3,HERG3,KCNH7,Kv11.3 |
| Uniprot Accession | Q9NS40,O54852 |
| Uniprot Entry Name | KCNH7_HUMAN,KCNH7_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000184611 |
| Target Classification | N/A |
The target: KCNH7, gene name: KCNH7, also named as ERG3, HERG3, Kv11.3. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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