Anti-KCIP1/ KCNIP1/ KCHIP1 monoclonal antibody

Anti-KCIP1/ KCNIP1/ KCHIP1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNIP1/KCNIP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0667-Ab-1/ GM-Tg-hg-MP0667-Ab-2Anti-Human KCNIP1 monoclonal antibodyHuman
GM-Tg-rg-MP0667-Ab-1/ GM-Tg-rg-MP0667-Ab-2Anti-Rat KCNIP1 monoclonal antibodyRat
GM-Tg-mg-MP0667-Ab-1/ GM-Tg-mg-MP0667-Ab-2Anti-Mouse KCNIP1 monoclonal antibodyMouse
GM-Tg-cynog-MP0667-Ab-1/ GM-Tg-cynog-MP0667-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNIP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0667-Ab-1/ GM-Tg-felg-MP0667-Ab-2Anti-Feline KCNIP1 monoclonal antibodyFeline
GM-Tg-cang-MP0667-Ab-1/ GM-Tg-cang-MP0667-Ab-2Anti-Canine KCNIP1 monoclonal antibodyCanine
GM-Tg-bovg-MP0667-Ab-1/ GM-Tg-bovg-MP0667-Ab-2Anti-Bovine KCNIP1 monoclonal antibodyBovine
GM-Tg-equg-MP0667-Ab-1/ GM-Tg-equg-MP0667-Ab-2Anti-Equine KCNIP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0667-Ab-1/ GM-Tg-hg-MP0667-Ab-2; GM-Tg-rg-MP0667-Ab-1/ GM-Tg-rg-MP0667-Ab-2;
GM-Tg-mg-MP0667-Ab-1/ GM-Tg-mg-MP0667-Ab-2; GM-Tg-cynog-MP0667-Ab-1/ GM-Tg-cynog-MP0667-Ab-2;
GM-Tg-felg-MP0667-Ab-1/ GM-Tg-felg-MP0667-Ab-2; GM-Tg-cang-MP0667-Ab-1/ GM-Tg-cang-MP0667-Ab-2;
GM-Tg-bovg-MP0667-Ab-1/ GM-Tg-bovg-MP0667-Ab-2; GM-Tg-equg-MP0667-Ab-1/ GM-Tg-equg-MP0667-Ab-2
Products NameAnti-KCNIP1 monoclonal antibody
Formatmab
Target NameKCNIP1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNIP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCIP1/ KCNIP1/ KCHIP1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0667
    Target NameKCNIP1
    Gene ID30820,70357,65023,706021,489125,101095884,541458,100059195
    Gene Symbol and SynonymsKCHIP1,Kchip1.2,KCNIP1,VABP
    Uniprot AccessionQ9NZI2,Q8R426
    Uniprot Entry NameKCIP1_HUMAN,KCIP1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000182132
    Target ClassificationIon Channel

    The target: KCNIP1, gene name: KCNIP1, also named as KCHIP1, VABP. This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.