Anti-CSEN/ KCNIP3/ DREAM monoclonal antibody

Anti-CSEN/ KCNIP3/ DREAM antibody for FACS & in-vivo assay

Target products collectionGo to KCNIP3/KCNIP3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0668-Ab-1/ GM-Tg-hg-MP0668-Ab-2Anti-Human KCNIP3 monoclonal antibodyHuman
GM-Tg-rg-MP0668-Ab-1/ GM-Tg-rg-MP0668-Ab-2Anti-Rat KCNIP3 monoclonal antibodyRat
GM-Tg-mg-MP0668-Ab-1/ GM-Tg-mg-MP0668-Ab-2Anti-Mouse KCNIP3 monoclonal antibodyMouse
GM-Tg-cynog-MP0668-Ab-1/ GM-Tg-cynog-MP0668-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNIP3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0668-Ab-1/ GM-Tg-felg-MP0668-Ab-2Anti-Feline KCNIP3 monoclonal antibodyFeline
GM-Tg-cang-MP0668-Ab-1/ GM-Tg-cang-MP0668-Ab-2Anti-Canine KCNIP3 monoclonal antibodyCanine
GM-Tg-bovg-MP0668-Ab-1/ GM-Tg-bovg-MP0668-Ab-2Anti-Bovine KCNIP3 monoclonal antibodyBovine
GM-Tg-equg-MP0668-Ab-1/ GM-Tg-equg-MP0668-Ab-2Anti-Equine KCNIP3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0668-Ab-1/ GM-Tg-hg-MP0668-Ab-2; GM-Tg-rg-MP0668-Ab-1/ GM-Tg-rg-MP0668-Ab-2;
GM-Tg-mg-MP0668-Ab-1/ GM-Tg-mg-MP0668-Ab-2; GM-Tg-cynog-MP0668-Ab-1/ GM-Tg-cynog-MP0668-Ab-2;
GM-Tg-felg-MP0668-Ab-1/ GM-Tg-felg-MP0668-Ab-2; GM-Tg-cang-MP0668-Ab-1/ GM-Tg-cang-MP0668-Ab-2;
GM-Tg-bovg-MP0668-Ab-1/ GM-Tg-bovg-MP0668-Ab-2; GM-Tg-equg-MP0668-Ab-1/ GM-Tg-equg-MP0668-Ab-2
Products NameAnti-KCNIP3 monoclonal antibody
Formatmab
Target NameKCNIP3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNIP3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CSEN/ KCNIP3/ DREAM VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0668
    Target NameKCNIP3
    Gene ID30818,56461,65199,704307,100856050,101087056,513316,100062637
    Gene Symbol and Synonyms4933407H12Rik,CSEN,DREAM,KCHIP3,KCNIP3,rKChIP3
    Uniprot AccessionQ9Y2W7,Q9JM47,Q17QD9
    Uniprot Entry NameCSEN_HUMAN,CSEN_RAT,CSEN_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000115041
    Target ClassificationN/A

    The target: KCNIP3, gene name: KCNIP3, also named as CSEN, DREAM, KCHIP3. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.