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Anti-KCIP4/ KCNIP4/ CALP monoclonal antibody
Anti-KCIP4/ KCNIP4/ CALP antibody for FACS & in-vivo assay
Go to KCNIP4/KCNIP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0669-Ab-1/ GM-Tg-hg-MP0669-Ab-2 | Anti-Human KCNIP4 monoclonal antibody | Human |
| GM-Tg-rg-MP0669-Ab-1/ GM-Tg-rg-MP0669-Ab-2 | Anti-Rat KCNIP4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0669-Ab-1/ GM-Tg-mg-MP0669-Ab-2 | Anti-Mouse KCNIP4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0669-Ab-1/ GM-Tg-cynog-MP0669-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNIP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0669-Ab-1/ GM-Tg-felg-MP0669-Ab-2 | Anti-Feline KCNIP4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0669-Ab-1/ GM-Tg-cang-MP0669-Ab-2 | Anti-Canine KCNIP4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0669-Ab-1/ GM-Tg-bovg-MP0669-Ab-2 | Anti-Bovine KCNIP4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0669-Ab-1/ GM-Tg-equg-MP0669-Ab-2 | Anti-Equine KCNIP4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0669-Ab-1/ GM-Tg-hg-MP0669-Ab-2; GM-Tg-rg-MP0669-Ab-1/ GM-Tg-rg-MP0669-Ab-2; GM-Tg-mg-MP0669-Ab-1/ GM-Tg-mg-MP0669-Ab-2; GM-Tg-cynog-MP0669-Ab-1/ GM-Tg-cynog-MP0669-Ab-2; GM-Tg-felg-MP0669-Ab-1/ GM-Tg-felg-MP0669-Ab-2; GM-Tg-cang-MP0669-Ab-1/ GM-Tg-cang-MP0669-Ab-2; GM-Tg-bovg-MP0669-Ab-1/ GM-Tg-bovg-MP0669-Ab-2; GM-Tg-equg-MP0669-Ab-1/ GM-Tg-equg-MP0669-Ab-2 |
| Products Name | Anti-KCNIP4 monoclonal antibody |
| Format | mab |
| Target Name | KCNIP4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNIP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCIP4/ KCNIP4/ CALP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000882 | Norway rat Kcnip4 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000882 | Norway rat Kcnip4 Lentivirus particle |
Target information
| Target ID | GM-MP0669 |
| Target Name | KCNIP4 |
| Gene ID | 80333,80334,259243,715577,479129,101084537,614299,100147377 |
| Gene Symbol and Synonyms | CALP,Calp250,KCHIP4,KChIP4a,KCNIP4 |
| Uniprot Accession | Q6PIL6,Q99MG9,Q2KI69 |
| Uniprot Entry Name | KCIP4_HUMAN,KCIP4_RAT,KCIP4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000185774 |
| Target Classification | N/A |
The target: KCNIP4, gene name: KCNIP4, also named as CALP, KCHIP4. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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