Anti-KCNKD/ KCNK13/ K2p13.1 monoclonal antibody

Anti-KCNKD/ KCNK13/ K2p13.1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNK13/KCNK13 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0678-Ab-1/ GM-Tg-hg-MP0678-Ab-2Anti-Human KCNK13 monoclonal antibodyHuman
GM-Tg-rg-MP0678-Ab-1/ GM-Tg-rg-MP0678-Ab-2Anti-Rat KCNK13 monoclonal antibodyRat
GM-Tg-mg-MP0678-Ab-1/ GM-Tg-mg-MP0678-Ab-2Anti-Mouse KCNK13 monoclonal antibodyMouse
GM-Tg-cynog-MP0678-Ab-1/ GM-Tg-cynog-MP0678-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNK13 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0678-Ab-1/ GM-Tg-felg-MP0678-Ab-2Anti-Feline KCNK13 monoclonal antibodyFeline
GM-Tg-cang-MP0678-Ab-1/ GM-Tg-cang-MP0678-Ab-2Anti-Canine KCNK13 monoclonal antibodyCanine
GM-Tg-bovg-MP0678-Ab-1/ GM-Tg-bovg-MP0678-Ab-2Anti-Bovine KCNK13 monoclonal antibodyBovine
GM-Tg-equg-MP0678-Ab-1/ GM-Tg-equg-MP0678-Ab-2Anti-Equine KCNK13 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0678-Ab-1/ GM-Tg-hg-MP0678-Ab-2; GM-Tg-rg-MP0678-Ab-1/ GM-Tg-rg-MP0678-Ab-2;
GM-Tg-mg-MP0678-Ab-1/ GM-Tg-mg-MP0678-Ab-2; GM-Tg-cynog-MP0678-Ab-1/ GM-Tg-cynog-MP0678-Ab-2;
GM-Tg-felg-MP0678-Ab-1/ GM-Tg-felg-MP0678-Ab-2; GM-Tg-cang-MP0678-Ab-1/ GM-Tg-cang-MP0678-Ab-2;
GM-Tg-bovg-MP0678-Ab-1/ GM-Tg-bovg-MP0678-Ab-2; GM-Tg-equg-MP0678-Ab-1/ GM-Tg-equg-MP0678-Ab-2
Products NameAnti-KCNK13 monoclonal antibody
Formatmab
Target NameKCNK13
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNK13 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNKD/ KCNK13/ K2p13.1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0678
    Target NameKCNK13
    Gene ID56659,217826,64120,695445,490829,101093780,787307,100062498
    Gene Symbol and SynonymsF730021E22Rik,Gm1570,Gm1685,K2p13.1,KCNK13,prdx1,THIK-1,THIK1
    Uniprot AccessionQ9HB14,Q9ERS0
    Uniprot Entry NameKCNKD_HUMAN,KCNKD_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000152315
    Target ClassificationN/A

    The target: KCNK13, gene name: KCNK13, also named as K2p13.1, THIK-1, THIK1. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.