Anti-KCNKH/ KCNK17/ K2p17.1 monoclonal antibody

Anti-KCNKH/ KCNK17/ K2p17.1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNK17/KCNK17 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0681-Ab-1/ GM-Tg-hg-MP0681-Ab-2Anti-Human KCNK17 monoclonal antibodyHuman
GM-Tg-rg-MP0681-Ab-1/ GM-Tg-rg-MP0681-Ab-2Anti-Rat KCNK17 monoclonal antibodyRat
GM-Tg-mg-MP0681-Ab-1/ GM-Tg-mg-MP0681-Ab-2Anti-Mouse KCNK17 monoclonal antibodyMouse
GM-Tg-cynog-MP0681-Ab-1/ GM-Tg-cynog-MP0681-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNK17 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0681-Ab-1/ GM-Tg-felg-MP0681-Ab-2Anti-Feline KCNK17 monoclonal antibodyFeline
GM-Tg-cang-MP0681-Ab-1/ GM-Tg-cang-MP0681-Ab-2Anti-Canine KCNK17 monoclonal antibodyCanine
GM-Tg-bovg-MP0681-Ab-1/ GM-Tg-bovg-MP0681-Ab-2Anti-Bovine KCNK17 monoclonal antibodyBovine
GM-Tg-equg-MP0681-Ab-1/ GM-Tg-equg-MP0681-Ab-2Anti-Equine KCNK17 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0681-Ab-1/ GM-Tg-hg-MP0681-Ab-2; GM-Tg-rg-MP0681-Ab-1/ GM-Tg-rg-MP0681-Ab-2;
GM-Tg-mg-MP0681-Ab-1/ GM-Tg-mg-MP0681-Ab-2; GM-Tg-cynog-MP0681-Ab-1/ GM-Tg-cynog-MP0681-Ab-2;
GM-Tg-felg-MP0681-Ab-1/ GM-Tg-felg-MP0681-Ab-2; GM-Tg-cang-MP0681-Ab-1/ GM-Tg-cang-MP0681-Ab-2;
GM-Tg-bovg-MP0681-Ab-1/ GM-Tg-bovg-MP0681-Ab-2; GM-Tg-equg-MP0681-Ab-1/ GM-Tg-equg-MP0681-Ab-2
Products NameAnti-KCNK17 monoclonal antibody
Formatmab
Target NameKCNK17
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNK17 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNKH/ KCNK17/ K2p17.1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0681
    Target NameKCNK17
    Gene ID89822,100039106,719574,119863932,101095979,282264,100065439
    Gene Symbol and SynonymsGm2048,K2p17.1,KCNK17,TALK-2,TALK2,TASK-4,TASK4
    Uniprot AccessionQ96T54
    Uniprot Entry NameKCNKH_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124780
    Target ClassificationN/A

    The target: KCNK17, gene name: KCNK17, also named as K2p17.1, TALK-2, TALK2, TASK-4, TASK4. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.