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Anti-KCNK2/ K2p2.1/ TPKC1 monoclonal antibody
Anti-KCNK2/ K2p2.1/ TPKC1 antibody for FACS & in-vivo assay
Go to KCNK2/KCNK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0682-Ab-1/ GM-Tg-hg-MP0682-Ab-2 | Anti-Human KCNK2 monoclonal antibody | Human |
| GM-Tg-rg-MP0682-Ab-1/ GM-Tg-rg-MP0682-Ab-2 | Anti-Rat KCNK2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0682-Ab-1/ GM-Tg-mg-MP0682-Ab-2 | Anti-Mouse KCNK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0682-Ab-1/ GM-Tg-cynog-MP0682-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0682-Ab-1/ GM-Tg-felg-MP0682-Ab-2 | Anti-Feline KCNK2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0682-Ab-1/ GM-Tg-cang-MP0682-Ab-2 | Anti-Canine KCNK2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0682-Ab-1/ GM-Tg-bovg-MP0682-Ab-2 | Anti-Bovine KCNK2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0682-Ab-1/ GM-Tg-equg-MP0682-Ab-2 | Anti-Equine KCNK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0682-Ab-1/ GM-Tg-hg-MP0682-Ab-2; GM-Tg-rg-MP0682-Ab-1/ GM-Tg-rg-MP0682-Ab-2; GM-Tg-mg-MP0682-Ab-1/ GM-Tg-mg-MP0682-Ab-2; GM-Tg-cynog-MP0682-Ab-1/ GM-Tg-cynog-MP0682-Ab-2; GM-Tg-felg-MP0682-Ab-1/ GM-Tg-felg-MP0682-Ab-2; GM-Tg-cang-MP0682-Ab-1/ GM-Tg-cang-MP0682-Ab-2; GM-Tg-bovg-MP0682-Ab-1/ GM-Tg-bovg-MP0682-Ab-2; GM-Tg-equg-MP0682-Ab-1/ GM-Tg-equg-MP0682-Ab-2 |
| Products Name | Anti-KCNK2 monoclonal antibody |
| Format | mab |
| Target Name | KCNK2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNK2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNK2/ K2p2.1/ TPKC1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002853 | human KCNK2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002853 | human KCNK2 Lentivirus particle |
| ORF Viral Vector | pGMLPm002489 | mouse Kcnk2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002489 | mouse Kcnk2 Lentivirus particle |
Target information
| Target ID | GM-MP0682 |
| Target Name | KCNK2 |
| Gene ID | 3776,16526,170899,708705,490295,101096695,282590,100050114 |
| Gene Symbol and Synonyms | A430027H14Rik,hTREK-1c,hTREK-1e,K2p2.1,KCNK2,rTREK1d,TPKC1,TREK,TREK-1,TREK1 |
| Uniprot Accession | O95069,Q920B6 |
| Uniprot Entry Name | KCNK2_HUMAN,KCNK2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000082482 |
| Target Classification | N/A |
The target: KCNK2, gene name: KCNK2, also named as K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e. This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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