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Anti-KCNK4/ K2p4.1/ TRAAK monoclonal antibody
Anti-KCNK4/ K2p4.1/ TRAAK antibody for FACS & in-vivo assay
Go to KCNK4/KCNK4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0683-Ab-1/ GM-Tg-hg-MP0683-Ab-2 | Anti-Human KCNK4 monoclonal antibody | Human |
| GM-Tg-rg-MP0683-Ab-1/ GM-Tg-rg-MP0683-Ab-2 | Anti-Rat KCNK4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0683-Ab-1/ GM-Tg-mg-MP0683-Ab-2 | Anti-Mouse KCNK4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0683-Ab-1/ GM-Tg-cynog-MP0683-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNK4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0683-Ab-1/ GM-Tg-felg-MP0683-Ab-2 | Anti-Feline KCNK4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0683-Ab-1/ GM-Tg-cang-MP0683-Ab-2 | Anti-Canine KCNK4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0683-Ab-1/ GM-Tg-bovg-MP0683-Ab-2 | Anti-Bovine KCNK4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0683-Ab-1/ GM-Tg-equg-MP0683-Ab-2 | Anti-Equine KCNK4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0683-Ab-1/ GM-Tg-hg-MP0683-Ab-2; GM-Tg-rg-MP0683-Ab-1/ GM-Tg-rg-MP0683-Ab-2; GM-Tg-mg-MP0683-Ab-1/ GM-Tg-mg-MP0683-Ab-2; GM-Tg-cynog-MP0683-Ab-1/ GM-Tg-cynog-MP0683-Ab-2; GM-Tg-felg-MP0683-Ab-1/ GM-Tg-felg-MP0683-Ab-2; GM-Tg-cang-MP0683-Ab-1/ GM-Tg-cang-MP0683-Ab-2; GM-Tg-bovg-MP0683-Ab-1/ GM-Tg-bovg-MP0683-Ab-2; GM-Tg-equg-MP0683-Ab-1/ GM-Tg-equg-MP0683-Ab-2 |
| Products Name | Anti-KCNK4 monoclonal antibody |
| Format | mab |
| Target Name | KCNK4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNK4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNK4/ K2p4.1/ TRAAK VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002503 | mouse Kcnk4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002503 | mouse Kcnk4 Lentivirus particle |
Target information
| Target ID | GM-MP0683 |
| Target Name | KCNK4 |
| Gene ID | 50801,16528,116489,612120,101099401,617184,100055490 |
| Gene Symbol and Synonyms | Catsperz,FHEIG,K2p4.1,KCNK4,KT4.1,MLZ-622,Tex40,TRAAK,TRAAK1,TRAAKt |
| Uniprot Accession | Q9NYG8,G3V8V5 |
| Uniprot Entry Name | KCNK4_HUMAN,KCNK4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000182450 |
| Target Classification | N/A |
The target: KCNK4, gene name: KCNK4, also named as K2p4.1, TRAAK, TRAAK1. This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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