Anti-KCNK6/ K2p6.1/ KCNK8 monoclonal antibody

Anti-KCNK6/ K2p6.1/ KCNK8 antibody for FACS & in-vivo assay

Target products collectionGo to KCNK6/KCNK6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0684-Ab-1/ GM-Tg-hg-MP0684-Ab-2Anti-Human KCNK6 monoclonal antibodyHuman
GM-Tg-rg-MP0684-Ab-1/ GM-Tg-rg-MP0684-Ab-2Anti-Rat KCNK6 monoclonal antibodyRat
GM-Tg-mg-MP0684-Ab-1/ GM-Tg-mg-MP0684-Ab-2Anti-Mouse KCNK6 monoclonal antibodyMouse
GM-Tg-cynog-MP0684-Ab-1/ GM-Tg-cynog-MP0684-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNK6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0684-Ab-1/ GM-Tg-felg-MP0684-Ab-2Anti-Feline KCNK6 monoclonal antibodyFeline
GM-Tg-cang-MP0684-Ab-1/ GM-Tg-cang-MP0684-Ab-2Anti-Canine KCNK6 monoclonal antibodyCanine
GM-Tg-bovg-MP0684-Ab-1/ GM-Tg-bovg-MP0684-Ab-2Anti-Bovine KCNK6 monoclonal antibodyBovine
GM-Tg-equg-MP0684-Ab-1/ GM-Tg-equg-MP0684-Ab-2Anti-Equine KCNK6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0684-Ab-1/ GM-Tg-hg-MP0684-Ab-2; GM-Tg-rg-MP0684-Ab-1/ GM-Tg-rg-MP0684-Ab-2;
GM-Tg-mg-MP0684-Ab-1/ GM-Tg-mg-MP0684-Ab-2; GM-Tg-cynog-MP0684-Ab-1/ GM-Tg-cynog-MP0684-Ab-2;
GM-Tg-felg-MP0684-Ab-1/ GM-Tg-felg-MP0684-Ab-2; GM-Tg-cang-MP0684-Ab-1/ GM-Tg-cang-MP0684-Ab-2;
GM-Tg-bovg-MP0684-Ab-1/ GM-Tg-bovg-MP0684-Ab-2; GM-Tg-equg-MP0684-Ab-1/ GM-Tg-equg-MP0684-Ab-2
Products NameAnti-KCNK6 monoclonal antibody
Formatmab
Target NameKCNK6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNK6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNK6/ K2p6.1/ KCNK8 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0684
    Target NameKCNK6
    Gene ID9424,52150,116491,714912,484531,101095938,785418,100064140
    Gene Symbol and SynonymsD7Ertd764e,K2p6.1,KCNK6,KCNK8,TOSS,TWIK-2,TWIK2
    Uniprot AccessionQ9Y257
    Uniprot Entry NameKCNK6_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000099337
    Target ClassificationN/A

    The target: KCNK6, gene name: KCNK6, also named as K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.