Anti-KCMB1/ KCNMB1/ BKbeta1 monoclonal antibody

Anti-KCMB1/ KCNMB1/ BKbeta1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNMB1/KCNMB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0686-Ab-1/ GM-Tg-hg-MP0686-Ab-2Anti-Human KCNMB1 monoclonal antibodyHuman
GM-Tg-rg-MP0686-Ab-1/ GM-Tg-rg-MP0686-Ab-2Anti-Rat KCNMB1 monoclonal antibodyRat
GM-Tg-mg-MP0686-Ab-1/ GM-Tg-mg-MP0686-Ab-2Anti-Mouse KCNMB1 monoclonal antibodyMouse
GM-Tg-cynog-MP0686-Ab-1/ GM-Tg-cynog-MP0686-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNMB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0686-Ab-1/ GM-Tg-felg-MP0686-Ab-2Anti-Feline KCNMB1 monoclonal antibodyFeline
GM-Tg-cang-MP0686-Ab-1/ GM-Tg-cang-MP0686-Ab-2Anti-Canine KCNMB1 monoclonal antibodyCanine
GM-Tg-bovg-MP0686-Ab-1/ GM-Tg-bovg-MP0686-Ab-2Anti-Bovine KCNMB1 monoclonal antibodyBovine
GM-Tg-equg-MP0686-Ab-1/ GM-Tg-equg-MP0686-Ab-2Anti-Equine KCNMB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0686-Ab-1/ GM-Tg-hg-MP0686-Ab-2; GM-Tg-rg-MP0686-Ab-1/ GM-Tg-rg-MP0686-Ab-2;
GM-Tg-mg-MP0686-Ab-1/ GM-Tg-mg-MP0686-Ab-2; GM-Tg-cynog-MP0686-Ab-1/ GM-Tg-cynog-MP0686-Ab-2;
GM-Tg-felg-MP0686-Ab-1/ GM-Tg-felg-MP0686-Ab-2; GM-Tg-cang-MP0686-Ab-1/ GM-Tg-cang-MP0686-Ab-2;
GM-Tg-bovg-MP0686-Ab-1/ GM-Tg-bovg-MP0686-Ab-2; GM-Tg-equg-MP0686-Ab-1/ GM-Tg-equg-MP0686-Ab-2
Products NameAnti-KCNMB1 monoclonal antibody
Formatmab
Target NameKCNMB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNMB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCMB1/ KCNMB1/ BKbeta1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0686
    Target NameKCNMB1
    Gene ID3779,16533,29747,700624,403983,101096637,407176,100059234
    Gene Symbol and SynonymsBKbeta,BKbeta1,hbeta1,hslo-beta,K(VCA)beta,k(VCA)beta-1,KCNMB1,SLO-BETA,slo-beta-1
    Uniprot AccessionQ16558,P97678,Q28266,Q28067
    Uniprot Entry NameKCMB1_HUMAN,KCMB1_RAT,KCMB1_CANLF,KCMB1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000145936
    Target ClassificationN/A

    The target: KCNMB1, gene name: KCNMB1, also named as BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.