Anti-KCMB3/ KCNMB3/ BKBETA3 monoclonal antibody

Anti-KCMB3/ KCNMB3/ BKBETA3 antibody for FACS & in-vivo assay

Target products collectionGo to KCNMB3/KCNMB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0688-Ab-1/ GM-Tg-hg-MP0688-Ab-2Anti-Human KCNMB3 monoclonal antibodyHuman
GM-Tg-rg-MP0688-Ab-1/ GM-Tg-rg-MP0688-Ab-2Anti-Rat KCNMB3 monoclonal antibodyRat
GM-Tg-mg-MP0688-Ab-1/ GM-Tg-mg-MP0688-Ab-2Anti-Mouse KCNMB3 monoclonal antibodyMouse
GM-Tg-cynog-MP0688-Ab-1/ GM-Tg-cynog-MP0688-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNMB3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0688-Ab-1/ GM-Tg-felg-MP0688-Ab-2Anti-Feline KCNMB3 monoclonal antibodyFeline
GM-Tg-cang-MP0688-Ab-1/ GM-Tg-cang-MP0688-Ab-2Anti-Canine KCNMB3 monoclonal antibodyCanine
GM-Tg-bovg-MP0688-Ab-1/ GM-Tg-bovg-MP0688-Ab-2Anti-Bovine KCNMB3 monoclonal antibodyBovine
GM-Tg-equg-MP0688-Ab-1/ GM-Tg-equg-MP0688-Ab-2Anti-Equine KCNMB3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0688-Ab-1/ GM-Tg-hg-MP0688-Ab-2; GM-Tg-rg-MP0688-Ab-1/ GM-Tg-rg-MP0688-Ab-2;
GM-Tg-mg-MP0688-Ab-1/ GM-Tg-mg-MP0688-Ab-2; GM-Tg-cynog-MP0688-Ab-1/ GM-Tg-cynog-MP0688-Ab-2;
GM-Tg-felg-MP0688-Ab-1/ GM-Tg-felg-MP0688-Ab-2; GM-Tg-cang-MP0688-Ab-1/ GM-Tg-cang-MP0688-Ab-2;
GM-Tg-bovg-MP0688-Ab-1/ GM-Tg-bovg-MP0688-Ab-2; GM-Tg-equg-MP0688-Ab-1/ GM-Tg-equg-MP0688-Ab-2
Products NameAnti-KCNMB3 monoclonal antibody
Formatmab
Target NameKCNMB3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNMB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCMB3/ KCNMB3/ BKBETA3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0688
    Target NameKCNMB3
    Gene ID27094,100502876,310303,709856,488085,101097167,539609,100065646
    Gene Symbol and SynonymsBKBETA3,EG435726,Gm5707,HBETA3,K(VCA)BETA-3,KCNMB2,KCNMB3,KCNMBL,SLO-BETA-3,SLOBETA3
    Uniprot AccessionQ9NPA1,A7VL23
    Uniprot Entry NameKCMB3_HUMAN,KCMB3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000171121
    Target ClassificationIon Channel

    The target: KCNMB3, gene name: KCNMB3, also named as BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.