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Anti-KCNS3/ KV9.3 monoclonal antibody
Anti-KCNS3/ KV9.3 antibody for FACS & in-vivo assay
Go to KCNS3/KCNS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0691-Ab-1/ GM-Tg-hg-MP0691-Ab-2 | Anti-Human KCNS3 monoclonal antibody | Human |
| GM-Tg-rg-MP0691-Ab-1/ GM-Tg-rg-MP0691-Ab-2 | Anti-Rat KCNS3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0691-Ab-1/ GM-Tg-mg-MP0691-Ab-2 | Anti-Mouse KCNS3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0691-Ab-1/ GM-Tg-cynog-MP0691-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNS3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0691-Ab-1/ GM-Tg-felg-MP0691-Ab-2 | Anti-Feline KCNS3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0691-Ab-1/ GM-Tg-cang-MP0691-Ab-2 | Anti-Canine KCNS3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0691-Ab-1/ GM-Tg-bovg-MP0691-Ab-2 | Anti-Bovine KCNS3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0691-Ab-1/ GM-Tg-equg-MP0691-Ab-2 | Anti-Equine KCNS3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0691-Ab-1/ GM-Tg-hg-MP0691-Ab-2; GM-Tg-rg-MP0691-Ab-1/ GM-Tg-rg-MP0691-Ab-2; GM-Tg-mg-MP0691-Ab-1/ GM-Tg-mg-MP0691-Ab-2; GM-Tg-cynog-MP0691-Ab-1/ GM-Tg-cynog-MP0691-Ab-2; GM-Tg-felg-MP0691-Ab-1/ GM-Tg-felg-MP0691-Ab-2; GM-Tg-cang-MP0691-Ab-1/ GM-Tg-cang-MP0691-Ab-2; GM-Tg-bovg-MP0691-Ab-1/ GM-Tg-bovg-MP0691-Ab-2; GM-Tg-equg-MP0691-Ab-1/ GM-Tg-equg-MP0691-Ab-2 |
| Products Name | Anti-KCNS3 monoclonal antibody |
| Format | mab |
| Target Name | KCNS3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNS3/ KV9.3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0691 |
| Target Name | KCNS3 |
| Gene ID | 3790,238076,83588,700065,482982,101081796,541460,100056640 |
| Gene Symbol and Synonyms | KCNS3,KV9.3 |
| Uniprot Accession | Q9BQ31,O88759 |
| Uniprot Entry Name | KCNS3_HUMAN,KCNS3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000170745 |
| Target Classification | N/A |
The target: KCNS3, gene name: KCNS3, also named as KV9.3. Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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