Anti-KELL/ KEL/ CD238 monoclonal antibody

Anti-KELL/ KEL/ CD238 antibody for FACS & in-vivo assay

Target products collectionGo to KEL/KEL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0694-Ab-1/ GM-Tg-hg-MP0694-Ab-2Anti-Human KEL monoclonal antibodyHuman
GM-Tg-rg-MP0694-Ab-1/ GM-Tg-rg-MP0694-Ab-2Anti-Rat KEL monoclonal antibodyRat
GM-Tg-mg-MP0694-Ab-1/ GM-Tg-mg-MP0694-Ab-2Anti-Mouse KEL monoclonal antibodyMouse
GM-Tg-cynog-MP0694-Ab-1/ GM-Tg-cynog-MP0694-Ab-2Anti-Cynomolgus/ Rhesus macaque KEL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0694-Ab-1/ GM-Tg-felg-MP0694-Ab-2Anti-Feline KEL monoclonal antibodyFeline
GM-Tg-cang-MP0694-Ab-1/ GM-Tg-cang-MP0694-Ab-2Anti-Canine KEL monoclonal antibodyCanine
GM-Tg-bovg-MP0694-Ab-1/ GM-Tg-bovg-MP0694-Ab-2Anti-Bovine KEL monoclonal antibodyBovine
GM-Tg-equg-MP0694-Ab-1/ GM-Tg-equg-MP0694-Ab-2Anti-Equine KEL monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0694-Ab-1/ GM-Tg-hg-MP0694-Ab-2; GM-Tg-rg-MP0694-Ab-1/ GM-Tg-rg-MP0694-Ab-2;
GM-Tg-mg-MP0694-Ab-1/ GM-Tg-mg-MP0694-Ab-2; GM-Tg-cynog-MP0694-Ab-1/ GM-Tg-cynog-MP0694-Ab-2;
GM-Tg-felg-MP0694-Ab-1/ GM-Tg-felg-MP0694-Ab-2; GM-Tg-cang-MP0694-Ab-1/ GM-Tg-cang-MP0694-Ab-2;
GM-Tg-bovg-MP0694-Ab-1/ GM-Tg-bovg-MP0694-Ab-2; GM-Tg-equg-MP0694-Ab-1/ GM-Tg-equg-MP0694-Ab-2
Products NameAnti-KEL monoclonal antibody
Formatmab
Target NameKEL
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KEL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KELL/ KEL/ CD238 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0694
    Target NameKEL
    Gene ID3792,23925,297025,703492,100855519,101098291,529060,100055587
    Gene Symbol and SynonymsCD238,ECE3,KEL,Kell,RGD1565470
    Uniprot AccessionP23276
    Uniprot Entry NameKELL_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000197993
    Target ClassificationN/A

    The target: KEL, gene name: KEL, also named as CD238, ECE3. This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.