Anti-KLOT/ KL/ HFTC3 monoclonal antibody

Anti-KLOT/ KL/ HFTC3 antibody for FACS & in-vivo assay

Target products collectionGo to KL/KL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0709-Ab-1/ GM-Tg-hg-MP0709-Ab-2Anti-Human KL monoclonal antibodyHuman
GM-Tg-rg-MP0709-Ab-1/ GM-Tg-rg-MP0709-Ab-2Anti-Rat KL monoclonal antibodyRat
GM-Tg-mg-MP0709-Ab-1/ GM-Tg-mg-MP0709-Ab-2Anti-Mouse KL monoclonal antibodyMouse
GM-Tg-cynog-MP0709-Ab-1/ GM-Tg-cynog-MP0709-Ab-2Anti-Cynomolgus/ Rhesus macaque KL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0709-Ab-1/ GM-Tg-felg-MP0709-Ab-2Anti-Feline KL monoclonal antibodyFeline
GM-Tg-cang-MP0709-Ab-1/ GM-Tg-cang-MP0709-Ab-2Anti-Canine KL monoclonal antibodyCanine
GM-Tg-bovg-MP0709-Ab-1/ GM-Tg-bovg-MP0709-Ab-2Anti-Bovine KL monoclonal antibodyBovine
GM-Tg-equg-MP0709-Ab-1/ GM-Tg-equg-MP0709-Ab-2Anti-Equine KL monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0709-Ab-1/ GM-Tg-hg-MP0709-Ab-2; GM-Tg-rg-MP0709-Ab-1/ GM-Tg-rg-MP0709-Ab-2;
GM-Tg-mg-MP0709-Ab-1/ GM-Tg-mg-MP0709-Ab-2; GM-Tg-cynog-MP0709-Ab-1/ GM-Tg-cynog-MP0709-Ab-2;
GM-Tg-felg-MP0709-Ab-1/ GM-Tg-felg-MP0709-Ab-2; GM-Tg-cang-MP0709-Ab-1/ GM-Tg-cang-MP0709-Ab-2;
GM-Tg-bovg-MP0709-Ab-1/ GM-Tg-bovg-MP0709-Ab-2; GM-Tg-equg-MP0709-Ab-1/ GM-Tg-equg-MP0709-Ab-2
Products NameAnti-KL monoclonal antibody
Formatmab
Target NameKL
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KLOT/ KL/ HFTC3 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0709-Ag-1klotho (KL) protein
    ORF Viral VectorpGMAD000264mouse Kl Adenovirus plasmid
    ORF Viral VectorpGMAAV000258house mouse Kl AAV plasmid
    ORF Viral VectorvGMAD000264mouse Kl Adenovirus particle
    ORF Viral VectorvGMAAV000258house mouse Kl AAV particle


    Target information

    Target IDGM-MP0709
    Target NameKL
    Gene ID9365,16591,83504,714042,100685604,101082617,784635,100064836
    Gene Symbol and Synonymsalpha-kl,HFTC3,KL,KLA
    Uniprot AccessionQ9UEF7,Q9Z2Y9
    Uniprot Entry NameKLOT_HUMAN,KLOT_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000133116
    Target ClassificationN/A

    The target: KL, gene name: KL, also named as HFTC3. This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.