Anti-KLRF1/ CLEC5C/ NKp80 monoclonal antibody

Anti-KLRF1/ CLEC5C/ NKp80 antibody for FACS & in-vivo assay

Target products collectionGo to KLRF1/KLRF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0714-Ab-1/ GM-Tg-hg-MP0714-Ab-2Anti-Human KLRF1 monoclonal antibodyHuman
GM-Tg-rg-MP0714-Ab-1/ GM-Tg-rg-MP0714-Ab-2Anti-Rat KLRF1 monoclonal antibodyRat
GM-Tg-mg-MP0714-Ab-1/ GM-Tg-mg-MP0714-Ab-2Anti-Mouse KLRF1 monoclonal antibodyMouse
GM-Tg-cynog-MP0714-Ab-1/ GM-Tg-cynog-MP0714-Ab-2Anti-Cynomolgus/ Rhesus macaque KLRF1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0714-Ab-1/ GM-Tg-felg-MP0714-Ab-2Anti-Feline KLRF1 monoclonal antibodyFeline
GM-Tg-cang-MP0714-Ab-1/ GM-Tg-cang-MP0714-Ab-2Anti-Canine KLRF1 monoclonal antibodyCanine
GM-Tg-bovg-MP0714-Ab-1/ GM-Tg-bovg-MP0714-Ab-2Anti-Bovine KLRF1 monoclonal antibodyBovine
GM-Tg-equg-MP0714-Ab-1/ GM-Tg-equg-MP0714-Ab-2Anti-Equine KLRF1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0714-Ab-1/ GM-Tg-hg-MP0714-Ab-2; GM-Tg-rg-MP0714-Ab-1/ GM-Tg-rg-MP0714-Ab-2;
GM-Tg-mg-MP0714-Ab-1/ GM-Tg-mg-MP0714-Ab-2; GM-Tg-cynog-MP0714-Ab-1/ GM-Tg-cynog-MP0714-Ab-2;
GM-Tg-felg-MP0714-Ab-1/ GM-Tg-felg-MP0714-Ab-2; GM-Tg-cang-MP0714-Ab-1/ GM-Tg-cang-MP0714-Ab-2;
GM-Tg-bovg-MP0714-Ab-1/ GM-Tg-bovg-MP0714-Ab-2; GM-Tg-equg-MP0714-Ab-1/ GM-Tg-equg-MP0714-Ab-2
Products NameAnti-KLRF1 monoclonal antibody
Formatmab
Target NameKLRF1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KLRF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KLRF1/ CLEC5C/ NKp80 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0714
    Target NameKLRF1
    Gene ID51348,574389,611429,101082756,100062092
    Gene Symbol and SynonymsCLEC5C,KLRF1,NKp80
    Uniprot AccessionQ9NZS2
    Uniprot Entry NameKLRF1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000150045
    Target ClassificationN/A

    The target: KLRF1, gene name: KLRF1, also named as CLEC5C, NKp80. KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.