Anti-KMT2E/ HDCMC04P/ MLL5 monoclonal antibody

Anti-KMT2E/ HDCMC04P/ MLL5 antibody for FACS & in-vivo assay

Target products collectionGo to KMT2E/KMT2E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0716-Ab-1/ GM-Tg-hg-MP0716-Ab-2Anti-Human KMT2E monoclonal antibodyHuman
GM-Tg-rg-MP0716-Ab-1/ GM-Tg-rg-MP0716-Ab-2Anti-Rat KMT2E monoclonal antibodyRat
GM-Tg-mg-MP0716-Ab-1/ GM-Tg-mg-MP0716-Ab-2Anti-Mouse KMT2E monoclonal antibodyMouse
GM-Tg-cynog-MP0716-Ab-1/ GM-Tg-cynog-MP0716-Ab-2Anti-Cynomolgus/ Rhesus macaque KMT2E monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0716-Ab-1/ GM-Tg-felg-MP0716-Ab-2Anti-Feline KMT2E monoclonal antibodyFeline
GM-Tg-cang-MP0716-Ab-1/ GM-Tg-cang-MP0716-Ab-2Anti-Canine KMT2E monoclonal antibodyCanine
GM-Tg-bovg-MP0716-Ab-1/ GM-Tg-bovg-MP0716-Ab-2Anti-Bovine KMT2E monoclonal antibodyBovine
GM-Tg-equg-MP0716-Ab-1/ GM-Tg-equg-MP0716-Ab-2Anti-Equine KMT2E monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0716-Ab-1/ GM-Tg-hg-MP0716-Ab-2; GM-Tg-rg-MP0716-Ab-1/ GM-Tg-rg-MP0716-Ab-2;
GM-Tg-mg-MP0716-Ab-1/ GM-Tg-mg-MP0716-Ab-2; GM-Tg-cynog-MP0716-Ab-1/ GM-Tg-cynog-MP0716-Ab-2;
GM-Tg-felg-MP0716-Ab-1/ GM-Tg-felg-MP0716-Ab-2; GM-Tg-cang-MP0716-Ab-1/ GM-Tg-cang-MP0716-Ab-2;
GM-Tg-bovg-MP0716-Ab-1/ GM-Tg-bovg-MP0716-Ab-2; GM-Tg-equg-MP0716-Ab-1/ GM-Tg-equg-MP0716-Ab-2
Products NameAnti-KMT2E monoclonal antibody
Formatmab
Target NameKMT2E
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KMT2E benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KMT2E/ HDCMC04P/ MLL5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0716
    Target NameKMT2E
    Gene ID55904,69188,311968,697233,475895,101084945,539121,100058928
    Gene Symbol and Synonyms1810033J14Rik,9530077A04Rik,D230038D11Rik,HDCMC04P,KMT2E,MLL5,NKp44L,ODLURO,SETD5B
    Uniprot AccessionQ8IZD2
    Uniprot Entry NameKMT2E_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000005483
    Target ClassificationN/A

    The target: KMT2E, gene name: KMT2E, also named as HDCMC04P, MLL5, NKp44L. This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.