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Anti-K2C1/ KRT1/ CK1 monoclonal antibody
Anti-K2C1/ KRT1/ CK1 antibody for FACS & in-vivo assay
Go to KRT1/KRT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0719-Ab-1/ GM-Tg-hg-MP0719-Ab-2 | Anti-Human KRT1 monoclonal antibody | Human |
| GM-Tg-rg-MP0719-Ab-1/ GM-Tg-rg-MP0719-Ab-2 | Anti-Rat KRT1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0719-Ab-1/ GM-Tg-mg-MP0719-Ab-2 | Anti-Mouse KRT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0719-Ab-1/ GM-Tg-cynog-MP0719-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KRT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0719-Ab-1/ GM-Tg-felg-MP0719-Ab-2 | Anti-Feline KRT1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0719-Ab-1/ GM-Tg-cang-MP0719-Ab-2 | Anti-Canine KRT1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0719-Ab-1/ GM-Tg-bovg-MP0719-Ab-2 | Anti-Bovine KRT1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0719-Ab-1/ GM-Tg-equg-MP0719-Ab-2 | Anti-Equine KRT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0719-Ab-1/ GM-Tg-hg-MP0719-Ab-2; GM-Tg-rg-MP0719-Ab-1/ GM-Tg-rg-MP0719-Ab-2; GM-Tg-mg-MP0719-Ab-1/ GM-Tg-mg-MP0719-Ab-2; GM-Tg-cynog-MP0719-Ab-1/ GM-Tg-cynog-MP0719-Ab-2; GM-Tg-felg-MP0719-Ab-1/ GM-Tg-felg-MP0719-Ab-2; GM-Tg-cang-MP0719-Ab-1/ GM-Tg-cang-MP0719-Ab-2; GM-Tg-bovg-MP0719-Ab-1/ GM-Tg-bovg-MP0719-Ab-2; GM-Tg-equg-MP0719-Ab-1/ GM-Tg-equg-MP0719-Ab-2 |
| Products Name | Anti-KRT1 monoclonal antibody |
| Format | mab |
| Target Name | KRT1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KRT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species K2C1/ KRT1/ CK1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAAV000335 | Norway rat Krt1 AAV plasmid |
| ORF Viral Vector | vGMAAV000335 | Norway rat Krt1 AAV particle |
Target information
| Target ID | GM-MP0719 |
| Target Name | KRT1 |
| Gene ID | 3848,16678,300250,699320,444857,101101483,100301161,100063302 |
| Gene Symbol and Synonyms | AEI2,CK1,EHK,EHK1,EPPK,K1,Kb1,KER1,Krt-2.1,KRT1,KRT1A,Krt2-1,Krt86,NEPPK |
| Uniprot Accession | P04264,Q6IMF3,Q6EIY9 |
| Uniprot Entry Name | K2C1_HUMAN,K2C1_RAT,K2C1_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000167768 |
| Target Classification | N/A |
The target: KRT1, gene name: KRT1, also named as CK1, EHK, EHK1, EPPK, K1A, NEPPK, KRT1. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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