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Anti-LAT/ IMD521/ pp36 monoclonal antibody
Anti-LAT/ IMD521/ pp36 antibody for FACS & in-vivo assay
Go to LAT/LAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0722-Ab-1/ GM-Tg-hg-MP0722-Ab-2 | Anti-Human LAT monoclonal antibody | Human |
| GM-Tg-rg-MP0722-Ab-1/ GM-Tg-rg-MP0722-Ab-2 | Anti-Rat LAT monoclonal antibody | Rat |
| GM-Tg-mg-MP0722-Ab-1/ GM-Tg-mg-MP0722-Ab-2 | Anti-Mouse LAT monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0722-Ab-1/ GM-Tg-cynog-MP0722-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LAT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0722-Ab-1/ GM-Tg-felg-MP0722-Ab-2 | Anti-Feline LAT monoclonal antibody | Feline |
| GM-Tg-cang-MP0722-Ab-1/ GM-Tg-cang-MP0722-Ab-2 | Anti-Canine LAT monoclonal antibody | Canine |
| GM-Tg-bovg-MP0722-Ab-1/ GM-Tg-bovg-MP0722-Ab-2 | Anti-Bovine LAT monoclonal antibody | Bovine |
| GM-Tg-equg-MP0722-Ab-1/ GM-Tg-equg-MP0722-Ab-2 | Anti-Equine LAT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0722-Ab-1/ GM-Tg-hg-MP0722-Ab-2; GM-Tg-rg-MP0722-Ab-1/ GM-Tg-rg-MP0722-Ab-2; GM-Tg-mg-MP0722-Ab-1/ GM-Tg-mg-MP0722-Ab-2; GM-Tg-cynog-MP0722-Ab-1/ GM-Tg-cynog-MP0722-Ab-2; GM-Tg-felg-MP0722-Ab-1/ GM-Tg-felg-MP0722-Ab-2; GM-Tg-cang-MP0722-Ab-1/ GM-Tg-cang-MP0722-Ab-2; GM-Tg-bovg-MP0722-Ab-1/ GM-Tg-bovg-MP0722-Ab-2; GM-Tg-equg-MP0722-Ab-1/ GM-Tg-equg-MP0722-Ab-2 |
| Products Name | Anti-LAT monoclonal antibody |
| Format | mab |
| Target Name | LAT |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LAT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LAT/ IMD521/ pp36 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000495 | human LAT Lentivirus plasmid |
| ORF Viral Vector | vGMAP000058 | Human LAT Adenovirus particle |
| ORF Viral Vector | vGMLP000495 | human LAT Lentivirus particle |
| ORF Viral Vector | pGMAP000058 | Human LAT Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000405 | mouse Lat Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000405 | mouse Lat Lentivirus particle |
Target information
| Target ID | GM-MP0722 |
| Target Name | LAT |
| Gene ID | 27040,16797,81511,704656,607947,101093319,514735,100064430 |
| Gene Symbol and Synonyms | IMD52,LAT,LAT1,p36-38,pp36 |
| Uniprot Accession | O43561,O70601 |
| Uniprot Entry Name | LAT_HUMAN,LAT_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000213658 |
| Target Classification | N/A |
The target: LAT, gene name: LAT, also named as IMD521, pp36, LAT. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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