Anti-LHPL5/ LHFPL5/ DFNB67 monoclonal antibody

Anti-LHPL5/ LHFPL5/ DFNB67 antibody for FACS & in-vivo assay

Target products collectionGo to LHFPL5/LHFPL5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0730-Ab-1/ GM-Tg-hg-MP0730-Ab-2Anti-Human LHFPL5 monoclonal antibodyHuman
GM-Tg-rg-MP0730-Ab-1/ GM-Tg-rg-MP0730-Ab-2Anti-Rat LHFPL5 monoclonal antibodyRat
GM-Tg-mg-MP0730-Ab-1/ GM-Tg-mg-MP0730-Ab-2Anti-Mouse LHFPL5 monoclonal antibodyMouse
GM-Tg-cynog-MP0730-Ab-1/ GM-Tg-cynog-MP0730-Ab-2Anti-Cynomolgus/ Rhesus macaque LHFPL5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0730-Ab-1/ GM-Tg-felg-MP0730-Ab-2Anti-Feline LHFPL5 monoclonal antibodyFeline
GM-Tg-cang-MP0730-Ab-1/ GM-Tg-cang-MP0730-Ab-2Anti-Canine LHFPL5 monoclonal antibodyCanine
GM-Tg-bovg-MP0730-Ab-1/ GM-Tg-bovg-MP0730-Ab-2Anti-Bovine LHFPL5 monoclonal antibodyBovine
GM-Tg-equg-MP0730-Ab-1/ GM-Tg-equg-MP0730-Ab-2Anti-Equine LHFPL5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0730-Ab-1/ GM-Tg-hg-MP0730-Ab-2; GM-Tg-rg-MP0730-Ab-1/ GM-Tg-rg-MP0730-Ab-2;
GM-Tg-mg-MP0730-Ab-1/ GM-Tg-mg-MP0730-Ab-2; GM-Tg-cynog-MP0730-Ab-1/ GM-Tg-cynog-MP0730-Ab-2;
GM-Tg-felg-MP0730-Ab-1/ GM-Tg-felg-MP0730-Ab-2; GM-Tg-cang-MP0730-Ab-1/ GM-Tg-cang-MP0730-Ab-2;
GM-Tg-bovg-MP0730-Ab-1/ GM-Tg-bovg-MP0730-Ab-2; GM-Tg-equg-MP0730-Ab-1/ GM-Tg-equg-MP0730-Ab-2
Products NameAnti-LHFPL5 monoclonal antibody
Formatmab
Target NameLHFPL5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LHFPL5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LHPL5/ LHFPL5/ DFNB67 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0730
    Target NameLHFPL5
    Gene ID222662,328789,294303,718952,100856307,101090772,527838,100063366
    Gene Symbol and Synonyms9330179O15Rik,DFNB67,dJ510O8.8,hscy,LHFPL5,™HS
    Uniprot AccessionQ8TAF8,Q5PPI7
    Uniprot Entry NameLHPL5_HUMAN,LHPL5_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000197753
    Target ClassificationN/A

    The target: LHFPL5, gene name: LHFPL5, also named as DFNB67, ™HS, dJ510O8.8. This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.