Anti-LIRA2/ LILRA2/ CD85H monoclonal antibody

Anti-LIRA2/ LILRA2/ CD85H antibody for FACS & in-vivo assay

Target products collectionGo to LILRA2/LILRA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0732-Ab-1/ GM-Tg-hg-MP0732-Ab-2Anti-Human LILRA2 monoclonal antibodyHuman
GM-Tg-rg-MP0732-Ab-1/ GM-Tg-rg-MP0732-Ab-2Anti-Rat LILRA2 monoclonal antibodyRat
GM-Tg-mg-MP0732-Ab-1/ GM-Tg-mg-MP0732-Ab-2Anti-Mouse LILRA2 monoclonal antibodyMouse
GM-Tg-cynog-MP0732-Ab-1/ GM-Tg-cynog-MP0732-Ab-2Anti-Cynomolgus/ Rhesus macaque LILRA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0732-Ab-1/ GM-Tg-felg-MP0732-Ab-2Anti-Feline LILRA2 monoclonal antibodyFeline
GM-Tg-cang-MP0732-Ab-1/ GM-Tg-cang-MP0732-Ab-2Anti-Canine LILRA2 monoclonal antibodyCanine
GM-Tg-bovg-MP0732-Ab-1/ GM-Tg-bovg-MP0732-Ab-2Anti-Bovine LILRA2 monoclonal antibodyBovine
GM-Tg-equg-MP0732-Ab-1/ GM-Tg-equg-MP0732-Ab-2Anti-Equine LILRA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0732-Ab-1/ GM-Tg-hg-MP0732-Ab-2; GM-Tg-rg-MP0732-Ab-1/ GM-Tg-rg-MP0732-Ab-2;
GM-Tg-mg-MP0732-Ab-1/ GM-Tg-mg-MP0732-Ab-2; GM-Tg-cynog-MP0732-Ab-1/ GM-Tg-cynog-MP0732-Ab-2;
GM-Tg-felg-MP0732-Ab-1/ GM-Tg-felg-MP0732-Ab-2; GM-Tg-cang-MP0732-Ab-1/ GM-Tg-cang-MP0732-Ab-2;
GM-Tg-bovg-MP0732-Ab-1/ GM-Tg-bovg-MP0732-Ab-2; GM-Tg-equg-MP0732-Ab-1/ GM-Tg-equg-MP0732-Ab-2
Products NameAnti-LILRA2 monoclonal antibody
Formatmab
Target NameLILRA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LILRA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LIRA2/ LILRA2/ CD85H VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0732
    Target NameLILRA2
    Gene ID11027
    Gene Symbol and SynonymsCD85H,ILT1,LILRA2,LIR-7,LIR7
    Uniprot AccessionQ8N149
    Uniprot Entry NameLIRA2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000239998
    Target ClassificationN/A

    The target: LILRA2, gene name: LILRA2, also named as CD85H, ILT1, LIR-7, LIR7. This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.