Anti-LRBA/ BGL/ CDC4L monoclonal antibody

Anti-LRBA/ BGL/ CDC4L antibody for FACS & in-vivo assay

Target products collectionGo to LRBA/LRBA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0744-Ab-1/ GM-Tg-hg-MP0744-Ab-2Anti-Human LRBA monoclonal antibodyHuman
GM-Tg-rg-MP0744-Ab-1/ GM-Tg-rg-MP0744-Ab-2Anti-Rat LRBA monoclonal antibodyRat
GM-Tg-mg-MP0744-Ab-1/ GM-Tg-mg-MP0744-Ab-2Anti-Mouse LRBA monoclonal antibodyMouse
GM-Tg-cynog-MP0744-Ab-1/ GM-Tg-cynog-MP0744-Ab-2Anti-Cynomolgus/ Rhesus macaque LRBA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0744-Ab-1/ GM-Tg-felg-MP0744-Ab-2Anti-Feline LRBA monoclonal antibodyFeline
GM-Tg-cang-MP0744-Ab-1/ GM-Tg-cang-MP0744-Ab-2Anti-Canine LRBA monoclonal antibodyCanine
GM-Tg-bovg-MP0744-Ab-1/ GM-Tg-bovg-MP0744-Ab-2Anti-Bovine LRBA monoclonal antibodyBovine
GM-Tg-equg-MP0744-Ab-1/ GM-Tg-equg-MP0744-Ab-2Anti-Equine LRBA monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0744-Ab-1/ GM-Tg-hg-MP0744-Ab-2; GM-Tg-rg-MP0744-Ab-1/ GM-Tg-rg-MP0744-Ab-2;
GM-Tg-mg-MP0744-Ab-1/ GM-Tg-mg-MP0744-Ab-2; GM-Tg-cynog-MP0744-Ab-1/ GM-Tg-cynog-MP0744-Ab-2;
GM-Tg-felg-MP0744-Ab-1/ GM-Tg-felg-MP0744-Ab-2; GM-Tg-cang-MP0744-Ab-1/ GM-Tg-cang-MP0744-Ab-2;
GM-Tg-bovg-MP0744-Ab-1/ GM-Tg-bovg-MP0744-Ab-2; GM-Tg-equg-MP0744-Ab-1/ GM-Tg-equg-MP0744-Ab-2
Products NameAnti-LRBA monoclonal antibody
Formatmab
Target NameLRBA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRBA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRBA/ BGL/ CDC4L VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0744
    Target NameLRBA
    Gene ID987,80877,361975,693823,475463,101093432,524279,102149621
    Gene Symbol and SynonymsBGL,CDC4L,CVID8,D3Ertd775e,LAB300,LBA,LRBA
    Uniprot AccessionP50851
    Uniprot Entry NameLRBA_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000198589
    Target ClassificationN/A

    The target: LRBA, gene name: LRBA, also named as BGL, CDC4L, CVID8, LAB300, LBA. The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.