Anti-LRP1B/ LRP-1B/ LRP-DIT monoclonal antibody

Anti-LRP1B/ LRP-1B/ LRP-DIT antibody for FACS & in-vivo assay

Target products collectionGo to LRP1B/LRP1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0755-Ab-1/ GM-Tg-hg-MP0755-Ab-2Anti-Human LRP1B monoclonal antibodyHuman
GM-Tg-rg-MP0755-Ab-1/ GM-Tg-rg-MP0755-Ab-2Anti-Rat LRP1B monoclonal antibodyRat
GM-Tg-mg-MP0755-Ab-1/ GM-Tg-mg-MP0755-Ab-2Anti-Mouse LRP1B monoclonal antibodyMouse
GM-Tg-cynog-MP0755-Ab-1/ GM-Tg-cynog-MP0755-Ab-2Anti-Cynomolgus/ Rhesus macaque LRP1B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0755-Ab-1/ GM-Tg-felg-MP0755-Ab-2Anti-Feline LRP1B monoclonal antibodyFeline
GM-Tg-cang-MP0755-Ab-1/ GM-Tg-cang-MP0755-Ab-2Anti-Canine LRP1B monoclonal antibodyCanine
GM-Tg-bovg-MP0755-Ab-1/ GM-Tg-bovg-MP0755-Ab-2Anti-Bovine LRP1B monoclonal antibodyBovine
GM-Tg-equg-MP0755-Ab-1/ GM-Tg-equg-MP0755-Ab-2Anti-Equine LRP1B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0755-Ab-1/ GM-Tg-hg-MP0755-Ab-2; GM-Tg-rg-MP0755-Ab-1/ GM-Tg-rg-MP0755-Ab-2;
GM-Tg-mg-MP0755-Ab-1/ GM-Tg-mg-MP0755-Ab-2; GM-Tg-cynog-MP0755-Ab-1/ GM-Tg-cynog-MP0755-Ab-2;
GM-Tg-felg-MP0755-Ab-1/ GM-Tg-felg-MP0755-Ab-2; GM-Tg-cang-MP0755-Ab-1/ GM-Tg-cang-MP0755-Ab-2;
GM-Tg-bovg-MP0755-Ab-1/ GM-Tg-bovg-MP0755-Ab-2; GM-Tg-equg-MP0755-Ab-1/ GM-Tg-equg-MP0755-Ab-2
Products NameAnti-LRP1B monoclonal antibody
Formatmab
Target NameLRP1B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRP1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRP1B/ LRP-1B/ LRP-DIT VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0755
    Target NameLRP1B
    Gene ID53353,94217,311926,721791,476136,101082332,100336528,106781898
    Gene Symbol and Synonyms9630004P12Rik,AABR07051892.1,LRP-1B,LRP-DIT,LRP1B,LRPDIT
    Uniprot AccessionQ9NZR2
    Uniprot Entry NameLRP1B_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000168702
    Target ClassificationN/A

    The target: LRP1B, gene name: LRP1B, also named as LRP-1B, LRP-DIT, LRPDIT. This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.