Anti-LRP4/ CLSS/ CMS17 monoclonal antibody

Anti-LRP4/ CLSS/ CMS17 antibody for FACS & in-vivo assay

Target products collectionGo to LRP4/LRP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0757-Ab-1/ GM-Tg-hg-MP0757-Ab-2Anti-Human LRP4 monoclonal antibodyHuman
GM-Tg-rg-MP0757-Ab-1/ GM-Tg-rg-MP0757-Ab-2Anti-Rat LRP4 monoclonal antibodyRat
GM-Tg-mg-MP0757-Ab-1/ GM-Tg-mg-MP0757-Ab-2Anti-Mouse LRP4 monoclonal antibodyMouse
GM-Tg-cynog-MP0757-Ab-1/ GM-Tg-cynog-MP0757-Ab-2Anti-Cynomolgus/ Rhesus macaque LRP4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0757-Ab-1/ GM-Tg-felg-MP0757-Ab-2Anti-Feline LRP4 monoclonal antibodyFeline
GM-Tg-cang-MP0757-Ab-1/ GM-Tg-cang-MP0757-Ab-2Anti-Canine LRP4 monoclonal antibodyCanine
GM-Tg-bovg-MP0757-Ab-1/ GM-Tg-bovg-MP0757-Ab-2Anti-Bovine LRP4 monoclonal antibodyBovine
GM-Tg-equg-MP0757-Ab-1/ GM-Tg-equg-MP0757-Ab-2Anti-Equine LRP4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0757-Ab-1/ GM-Tg-hg-MP0757-Ab-2; GM-Tg-rg-MP0757-Ab-1/ GM-Tg-rg-MP0757-Ab-2;
GM-Tg-mg-MP0757-Ab-1/ GM-Tg-mg-MP0757-Ab-2; GM-Tg-cynog-MP0757-Ab-1/ GM-Tg-cynog-MP0757-Ab-2;
GM-Tg-felg-MP0757-Ab-1/ GM-Tg-felg-MP0757-Ab-2; GM-Tg-cang-MP0757-Ab-1/ GM-Tg-cang-MP0757-Ab-2;
GM-Tg-bovg-MP0757-Ab-1/ GM-Tg-bovg-MP0757-Ab-2; GM-Tg-equg-MP0757-Ab-1/ GM-Tg-equg-MP0757-Ab-2
Products NameAnti-LRP4 monoclonal antibody
Formatmab
Target NameLRP4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRP4/ CLSS/ CMS17 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0757
    Target NameLRP4
    Gene ID4038,228357,83469,714038,483628,101085829,504317,100057602
    Gene Symbol and Synonyms6430526J12Rik,CLSS,CMS17,D230026E03,LRP-4,LRP10,LRP4,mdig,MEGF7,SOST2
    Uniprot AccessionO75096,Q9QYP1
    Uniprot Entry NameLRP4_HUMAN,LRP4_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000134569
    Target ClassificationN/A

    The target: LRP4, gene name: LRP4, also named as CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2. This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.