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Anti-LRC8A/ LRRC8A/ AGM5 monoclonal antibody
Anti-LRC8A/ LRRC8A/ AGM5 antibody for FACS & in-vivo assay
Go to LRRC8A/LRRC8A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0767-Ab-1/ GM-Tg-hg-MP0767-Ab-2 | Anti-Human LRRC8A monoclonal antibody | Human |
| GM-Tg-rg-MP0767-Ab-1/ GM-Tg-rg-MP0767-Ab-2 | Anti-Rat LRRC8A monoclonal antibody | Rat |
| GM-Tg-mg-MP0767-Ab-1/ GM-Tg-mg-MP0767-Ab-2 | Anti-Mouse LRRC8A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0767-Ab-1/ GM-Tg-cynog-MP0767-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRRC8A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0767-Ab-1/ GM-Tg-felg-MP0767-Ab-2 | Anti-Feline LRRC8A monoclonal antibody | Feline |
| GM-Tg-cang-MP0767-Ab-1/ GM-Tg-cang-MP0767-Ab-2 | Anti-Canine LRRC8A monoclonal antibody | Canine |
| GM-Tg-bovg-MP0767-Ab-1/ GM-Tg-bovg-MP0767-Ab-2 | Anti-Bovine LRRC8A monoclonal antibody | Bovine |
| GM-Tg-equg-MP0767-Ab-1/ GM-Tg-equg-MP0767-Ab-2 | Anti-Equine LRRC8A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0767-Ab-1/ GM-Tg-hg-MP0767-Ab-2; GM-Tg-rg-MP0767-Ab-1/ GM-Tg-rg-MP0767-Ab-2; GM-Tg-mg-MP0767-Ab-1/ GM-Tg-mg-MP0767-Ab-2; GM-Tg-cynog-MP0767-Ab-1/ GM-Tg-cynog-MP0767-Ab-2; GM-Tg-felg-MP0767-Ab-1/ GM-Tg-felg-MP0767-Ab-2; GM-Tg-cang-MP0767-Ab-1/ GM-Tg-cang-MP0767-Ab-2; GM-Tg-bovg-MP0767-Ab-1/ GM-Tg-bovg-MP0767-Ab-2; GM-Tg-equg-MP0767-Ab-1/ GM-Tg-equg-MP0767-Ab-2 |
| Products Name | Anti-LRRC8A monoclonal antibody |
| Format | mab |
| Target Name | LRRC8A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LRRC8A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LRC8A/ LRRC8A/ AGM5 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000061 | human LRRC8A Adenovirus plasmid |
| ORF Viral Vector | vGMAD000061 | human LRRC8A Adenovirus particle |
| ORF Viral Vector | pGMLPm004384 | mouse Lrrc8a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004384 | mouse Lrrc8a Lentivirus particle |
Target information
| Target ID | GM-MP0767 |
| Target Name | LRRC8A |
| Gene ID | 56262,241296,311846,717074,491309,101082860,505605,100066843 |
| Gene Symbol and Synonyms | AGM5,ebo,HsLRRC8A,LLRC8A,LRRC8,LRRC8A,mKIAA1437,SWELL1 |
| Uniprot Accession | Q8IWT6,Q4V8I7 |
| Uniprot Entry Name | LRC8A_HUMAN,LRC8A_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136802 |
| Target Classification | N/A |
The target: LRRC8A, gene name: LRRC8A, also named as AGM5, LRRC8, SWELL1. This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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