Anti-LRC8B/ LRRC8B/ TA-LRRP monoclonal antibody

Anti-LRC8B/ LRRC8B/ TA-LRRP antibody for FACS & in-vivo assay

Target products collectionGo to LRRC8B/LRRC8B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0768-Ab-1/ GM-Tg-hg-MP0768-Ab-2Anti-Human LRRC8B monoclonal antibodyHuman
GM-Tg-rg-MP0768-Ab-1/ GM-Tg-rg-MP0768-Ab-2Anti-Rat LRRC8B monoclonal antibodyRat
GM-Tg-mg-MP0768-Ab-1/ GM-Tg-mg-MP0768-Ab-2Anti-Mouse LRRC8B monoclonal antibodyMouse
GM-Tg-cynog-MP0768-Ab-1/ GM-Tg-cynog-MP0768-Ab-2Anti-Cynomolgus/ Rhesus macaque LRRC8B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0768-Ab-1/ GM-Tg-felg-MP0768-Ab-2Anti-Feline LRRC8B monoclonal antibodyFeline
GM-Tg-cang-MP0768-Ab-1/ GM-Tg-cang-MP0768-Ab-2Anti-Canine LRRC8B monoclonal antibodyCanine
GM-Tg-bovg-MP0768-Ab-1/ GM-Tg-bovg-MP0768-Ab-2Anti-Bovine LRRC8B monoclonal antibodyBovine
GM-Tg-equg-MP0768-Ab-1/ GM-Tg-equg-MP0768-Ab-2Anti-Equine LRRC8B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0768-Ab-1/ GM-Tg-hg-MP0768-Ab-2; GM-Tg-rg-MP0768-Ab-1/ GM-Tg-rg-MP0768-Ab-2;
GM-Tg-mg-MP0768-Ab-1/ GM-Tg-mg-MP0768-Ab-2; GM-Tg-cynog-MP0768-Ab-1/ GM-Tg-cynog-MP0768-Ab-2;
GM-Tg-felg-MP0768-Ab-1/ GM-Tg-felg-MP0768-Ab-2; GM-Tg-cang-MP0768-Ab-1/ GM-Tg-cang-MP0768-Ab-2;
GM-Tg-bovg-MP0768-Ab-1/ GM-Tg-bovg-MP0768-Ab-2; GM-Tg-equg-MP0768-Ab-1/ GM-Tg-equg-MP0768-Ab-2
Products NameAnti-LRRC8B monoclonal antibody
Formatmab
Target NameLRRC8B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRRC8B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRC8B/ LRRC8B/ TA-LRRP VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0768
    Target NameLRRC8B
    Gene ID23507,433926,305135,100430724,479958,101082930,517584,100051898
    Gene Symbol and Synonyms2210408K08Rik,LRRC8B,mKIAA0231,RGD1563429,TA-LRRP,TALRRP
    Uniprot AccessionQ6P9F7
    Uniprot Entry NameLRC8B_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000197147
    Target ClassificationN/A

    The target: LRRC8B, gene name: LRRC8B, also named as TA-LRRP, TALRRP. Contributes to volume-sensitive anion channel activity. Involved in anion transmembrane transport. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.