Anti-LRC8C/ LRRC8C/ AD158 monoclonal antibody

Anti-LRC8C/ LRRC8C/ AD158 antibody for FACS & in-vivo assay

Target products collectionGo to LRRC8C/LRRC8C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0769-Ab-1/ GM-Tg-hg-MP0769-Ab-2Anti-Human LRRC8C monoclonal antibodyHuman
GM-Tg-rg-MP0769-Ab-1/ GM-Tg-rg-MP0769-Ab-2Anti-Rat LRRC8C monoclonal antibodyRat
GM-Tg-mg-MP0769-Ab-1/ GM-Tg-mg-MP0769-Ab-2Anti-Mouse LRRC8C monoclonal antibodyMouse
GM-Tg-cynog-MP0769-Ab-1/ GM-Tg-cynog-MP0769-Ab-2Anti-Cynomolgus/ Rhesus macaque LRRC8C monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0769-Ab-1/ GM-Tg-felg-MP0769-Ab-2Anti-Feline LRRC8C monoclonal antibodyFeline
GM-Tg-cang-MP0769-Ab-1/ GM-Tg-cang-MP0769-Ab-2Anti-Canine LRRC8C monoclonal antibodyCanine
GM-Tg-bovg-MP0769-Ab-1/ GM-Tg-bovg-MP0769-Ab-2Anti-Bovine LRRC8C monoclonal antibodyBovine
GM-Tg-equg-MP0769-Ab-1/ GM-Tg-equg-MP0769-Ab-2Anti-Equine LRRC8C monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0769-Ab-1/ GM-Tg-hg-MP0769-Ab-2; GM-Tg-rg-MP0769-Ab-1/ GM-Tg-rg-MP0769-Ab-2;
GM-Tg-mg-MP0769-Ab-1/ GM-Tg-mg-MP0769-Ab-2; GM-Tg-cynog-MP0769-Ab-1/ GM-Tg-cynog-MP0769-Ab-2;
GM-Tg-felg-MP0769-Ab-1/ GM-Tg-felg-MP0769-Ab-2; GM-Tg-cang-MP0769-Ab-1/ GM-Tg-cang-MP0769-Ab-2;
GM-Tg-bovg-MP0769-Ab-1/ GM-Tg-bovg-MP0769-Ab-2; GM-Tg-equg-MP0769-Ab-1/ GM-Tg-equg-MP0769-Ab-2
Products NameAnti-LRRC8C monoclonal antibody
Formatmab
Target NameLRRC8C
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRRC8C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRC8C/ LRRC8C/ AD158 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0769
    Target NameLRRC8C
    Gene ID84230,100604,289443,696086,490168,101083191,527708,100061419
    Gene Symbol and SynonymsAD158,E430036I04Rik,FAD158,LRRC8C,RGD1306585
    Uniprot AccessionQ8TDW0,Q498T9,A5PK13
    Uniprot Entry NameLRC8C_HUMAN,LRC8C_RAT,LRC8C_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000171488
    Target ClassificationN/A

    The target: LRRC8C, gene name: LRRC8C, also named as AD158, FAD158. Enables volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.