Anti-LRC8E/ LRRC8E monoclonal antibody

Anti-LRC8E/ LRRC8E antibody for FACS & in-vivo assay

Target products collectionGo to LRRC8E/LRRC8E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0771-Ab-1/ GM-Tg-hg-MP0771-Ab-2Anti-Human LRRC8E monoclonal antibodyHuman
GM-Tg-rg-MP0771-Ab-1/ GM-Tg-rg-MP0771-Ab-2Anti-Rat LRRC8E monoclonal antibodyRat
GM-Tg-mg-MP0771-Ab-1/ GM-Tg-mg-MP0771-Ab-2Anti-Mouse LRRC8E monoclonal antibodyMouse
GM-Tg-cynog-MP0771-Ab-1/ GM-Tg-cynog-MP0771-Ab-2Anti-Cynomolgus/ Rhesus macaque LRRC8E monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0771-Ab-1/ GM-Tg-felg-MP0771-Ab-2Anti-Feline LRRC8E monoclonal antibodyFeline
GM-Tg-cang-MP0771-Ab-1/ GM-Tg-cang-MP0771-Ab-2Anti-Canine LRRC8E monoclonal antibodyCanine
GM-Tg-bovg-MP0771-Ab-1/ GM-Tg-bovg-MP0771-Ab-2Anti-Bovine LRRC8E monoclonal antibodyBovine
GM-Tg-equg-MP0771-Ab-1/ GM-Tg-equg-MP0771-Ab-2Anti-Equine LRRC8E monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0771-Ab-1/ GM-Tg-hg-MP0771-Ab-2; GM-Tg-rg-MP0771-Ab-1/ GM-Tg-rg-MP0771-Ab-2;
GM-Tg-mg-MP0771-Ab-1/ GM-Tg-mg-MP0771-Ab-2; GM-Tg-cynog-MP0771-Ab-1/ GM-Tg-cynog-MP0771-Ab-2;
GM-Tg-felg-MP0771-Ab-1/ GM-Tg-felg-MP0771-Ab-2; GM-Tg-cang-MP0771-Ab-1/ GM-Tg-cang-MP0771-Ab-2;
GM-Tg-bovg-MP0771-Ab-1/ GM-Tg-bovg-MP0771-Ab-2; GM-Tg-equg-MP0771-Ab-1/ GM-Tg-equg-MP0771-Ab-2
Products NameAnti-LRRC8E monoclonal antibody
Formatmab
Target NameLRRC8E
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRRC8E benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRC8E/ LRRC8E VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0771
    Target NameLRRC8E
    Gene ID80131,72267,304203,706394,485003,101095552,507824,100060781
    Gene Symbol and Synonyms1810049O03Rik,LRRC8E,RGD1311979
    Uniprot AccessionQ6NSJ5,Q3KRC6
    Uniprot Entry NameLRC8E_HUMAN,LRC8E_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000171017
    Target ClassificationN/A

    The target: LRRC8E, gene name: LRRC8E, also named as . This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.