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Anti-MADD/ DENN/ IG20 monoclonal antibody
Anti-MADD/ DENN/ IG20 antibody for FACS & in-vivo assay
Go to MADD/MADD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0792-Ab-1/ GM-Tg-hg-MP0792-Ab-2 | Anti-Human MADD monoclonal antibody | Human |
| GM-Tg-rg-MP0792-Ab-1/ GM-Tg-rg-MP0792-Ab-2 | Anti-Rat MADD monoclonal antibody | Rat |
| GM-Tg-mg-MP0792-Ab-1/ GM-Tg-mg-MP0792-Ab-2 | Anti-Mouse MADD monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0792-Ab-1/ GM-Tg-cynog-MP0792-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MADD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0792-Ab-1/ GM-Tg-felg-MP0792-Ab-2 | Anti-Feline MADD monoclonal antibody | Feline |
| GM-Tg-cang-MP0792-Ab-1/ GM-Tg-cang-MP0792-Ab-2 | Anti-Canine MADD monoclonal antibody | Canine |
| GM-Tg-bovg-MP0792-Ab-1/ GM-Tg-bovg-MP0792-Ab-2 | Anti-Bovine MADD monoclonal antibody | Bovine |
| GM-Tg-equg-MP0792-Ab-1/ GM-Tg-equg-MP0792-Ab-2 | Anti-Equine MADD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0792-Ab-1/ GM-Tg-hg-MP0792-Ab-2; GM-Tg-rg-MP0792-Ab-1/ GM-Tg-rg-MP0792-Ab-2; GM-Tg-mg-MP0792-Ab-1/ GM-Tg-mg-MP0792-Ab-2; GM-Tg-cynog-MP0792-Ab-1/ GM-Tg-cynog-MP0792-Ab-2; GM-Tg-felg-MP0792-Ab-1/ GM-Tg-felg-MP0792-Ab-2; GM-Tg-cang-MP0792-Ab-1/ GM-Tg-cang-MP0792-Ab-2; GM-Tg-bovg-MP0792-Ab-1/ GM-Tg-bovg-MP0792-Ab-2; GM-Tg-equg-MP0792-Ab-1/ GM-Tg-equg-MP0792-Ab-2 |
| Products Name | Anti-MADD monoclonal antibody |
| Format | mab |
| Target Name | MADD |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MADD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MADD/ DENN/ IG20 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0792 |
| Target Name | MADD |
| Gene ID | 8567,228355,94193,713613,475982,101093297,534306,100051327 |
| Gene Symbol and Synonyms | 9630059K23Rik,DEEAH,DENN,IG20,MADD,NEDDISH,RAB3GEP,RabGEF,RabGEP |
| Uniprot Accession | Q8WXG6,O08873 |
| Uniprot Entry Name | MADD_HUMAN,MADD_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000110514 |
| Target Classification | N/A |
The target: MADD, gene name: MADD, also named as DENN, IG20, RAB3GEP. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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