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Anti-MALD2/ MARVELD2/ DFNB49 monoclonal antibody
Anti-MALD2/ MARVELD2/ DFNB49 antibody for FACS & in-vivo assay
Go to MARVELD2/MARVELD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0797-Ab-1/ GM-Tg-hg-MP0797-Ab-2 | Anti-Human MARVELD2 monoclonal antibody | Human |
| GM-Tg-rg-MP0797-Ab-1/ GM-Tg-rg-MP0797-Ab-2 | Anti-Rat MARVELD2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0797-Ab-1/ GM-Tg-mg-MP0797-Ab-2 | Anti-Mouse MARVELD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0797-Ab-1/ GM-Tg-cynog-MP0797-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MARVELD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0797-Ab-1/ GM-Tg-felg-MP0797-Ab-2 | Anti-Feline MARVELD2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0797-Ab-1/ GM-Tg-cang-MP0797-Ab-2 | Anti-Canine MARVELD2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0797-Ab-1/ GM-Tg-bovg-MP0797-Ab-2 | Anti-Bovine MARVELD2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0797-Ab-1/ GM-Tg-equg-MP0797-Ab-2 | Anti-Equine MARVELD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0797-Ab-1/ GM-Tg-hg-MP0797-Ab-2; GM-Tg-rg-MP0797-Ab-1/ GM-Tg-rg-MP0797-Ab-2; GM-Tg-mg-MP0797-Ab-1/ GM-Tg-mg-MP0797-Ab-2; GM-Tg-cynog-MP0797-Ab-1/ GM-Tg-cynog-MP0797-Ab-2; GM-Tg-felg-MP0797-Ab-1/ GM-Tg-felg-MP0797-Ab-2; GM-Tg-cang-MP0797-Ab-1/ GM-Tg-cang-MP0797-Ab-2; GM-Tg-bovg-MP0797-Ab-1/ GM-Tg-bovg-MP0797-Ab-2; GM-Tg-equg-MP0797-Ab-1/ GM-Tg-equg-MP0797-Ab-2 |
| Products Name | Anti-MARVELD2 monoclonal antibody |
| Format | mab |
| Target Name | MARVELD2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MARVELD2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MALD2/ MARVELD2/ DFNB49 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001688 | human MARVELD2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001688 | human MARVELD2 Lentivirus particle |
| ORF Viral Vector | pGMLPm005355 | mouse Marveld2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005355 | mouse Marveld2 Lentivirus particle |
Target information
| Target ID | GM-MP0797 |
| Target Name | MARVELD2 |
| Gene ID | 153562,218518,365657,700370,487240,102899726,541110,100073307 |
| Gene Symbol and Synonyms | DFNB49,MARVD2,MARVELD2,MRVLDC2,Tric,Trica,Tricb,Tricc |
| Uniprot Accession | Q8N4S9 |
| Uniprot Entry Name | MALD2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152939 |
| Target Classification | N/A |
The target: MARVELD2, gene name: MARVELD2, also named as DFNB49, MARVD2, MRVLDC2, Tric. The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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