Anti-MDGA1/ GPIM/ MAMDC3 monoclonal antibody

Anti-MDGA1/ GPIM/ MAMDC3 antibody for FACS & in-vivo assay

Target products collectionGo to MDGA1/MDGA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0802-Ab-1/ GM-Tg-hg-MP0802-Ab-2Anti-Human MDGA1 monoclonal antibodyHuman
GM-Tg-rg-MP0802-Ab-1/ GM-Tg-rg-MP0802-Ab-2Anti-Rat MDGA1 monoclonal antibodyRat
GM-Tg-mg-MP0802-Ab-1/ GM-Tg-mg-MP0802-Ab-2Anti-Mouse MDGA1 monoclonal antibodyMouse
GM-Tg-cynog-MP0802-Ab-1/ GM-Tg-cynog-MP0802-Ab-2Anti-Cynomolgus/ Rhesus macaque MDGA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0802-Ab-1/ GM-Tg-felg-MP0802-Ab-2Anti-Feline MDGA1 monoclonal antibodyFeline
GM-Tg-cang-MP0802-Ab-1/ GM-Tg-cang-MP0802-Ab-2Anti-Canine MDGA1 monoclonal antibodyCanine
GM-Tg-bovg-MP0802-Ab-1/ GM-Tg-bovg-MP0802-Ab-2Anti-Bovine MDGA1 monoclonal antibodyBovine
GM-Tg-equg-MP0802-Ab-1/ GM-Tg-equg-MP0802-Ab-2Anti-Equine MDGA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0802-Ab-1/ GM-Tg-hg-MP0802-Ab-2; GM-Tg-rg-MP0802-Ab-1/ GM-Tg-rg-MP0802-Ab-2;
GM-Tg-mg-MP0802-Ab-1/ GM-Tg-mg-MP0802-Ab-2; GM-Tg-cynog-MP0802-Ab-1/ GM-Tg-cynog-MP0802-Ab-2;
GM-Tg-felg-MP0802-Ab-1/ GM-Tg-felg-MP0802-Ab-2; GM-Tg-cang-MP0802-Ab-1/ GM-Tg-cang-MP0802-Ab-2;
GM-Tg-bovg-MP0802-Ab-1/ GM-Tg-bovg-MP0802-Ab-2; GM-Tg-equg-MP0802-Ab-1/ GM-Tg-equg-MP0802-Ab-2
Products NameAnti-MDGA1 monoclonal antibody
Formatmab
Target NameMDGA1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MDGA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MDGA1/ GPIM/ MAMDC3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0802
    Target NameMDGA1
    Gene ID266727,74762,309659,719423,474893,101083424,536481,100054042
    Gene Symbol and Synonyms1200011I03Rik,GPIM,MAMDC3,MDGA1
    Uniprot AccessionQ8NFP4,P85171
    Uniprot Entry NameMDGA1_HUMAN,MDGA1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000112139
    Target ClassificationN/A

    The target: MDGA1, gene name: MDGA1, also named as GPIM, MAMDC3. This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.